Volume 22, Issue 95 (8-2014)                   zumsj 2014, 22(95): 122-131 | Back to browse issues page

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sadeghi F, Khalaj-Kondori M, Hosseinpour Feizi M, Shaikhzadeh Hesari F. The Effect of Aqueous Extract of Boswellia on Spatial Learning and Memory in Adult Male Rats. zumsj. 2014; 22 (95) :122-131
URL: http://zums.ac.ir/journal/article-1-2886-en.html
Abstract:   (9909 Views)

Background and Objective: Learning is the acquisition of information about the world and memory is a mechanism to encode, store and retrieve the learned information. Weak memory and learning disorders are the most common cognitive problems. In the present study, the pharmacological effects of aqueous extract of Boswellia on learning and spatial memory in male rats was investigated using the Morris water maze (MWM) test. Materials and Methods: In this experimental study, 21 male rats were divided into 3 groups including a control group (distilled water) and two groups treated with aqueous extract of Boswellia (50 and 100 mg/kg) that received the treatment for 4 weeks. To evaluate learning ability of animals, Morris Water Maze was used. Results: In the first and the last day of training, all groups showed significant reduction in escape latency (P<0.0001) and traveled distance (P<0.0001). In the sixth day of training, both treatment groups showed significant reduction in escape latency (P<0.05) and traveled distance (P<0.05) in comparison with the control group. Conclusion: The results suggest that intake of Boswellia facilitates the learning and spatial memory formation in rats via Morris water maze test method. References 1- Sharifzadeh M, Sharifzadeh K, Naghdi N, Ghahremani MH, Roghani A. Posttraining intrahippocampal infusion of a protein kinase AII inhibitor impairs spatial memory retention in rats. J Neurosci Res. 2005 79(3): 392-400 2- Francis PT, Palmer AM, Snape M, Wilcock GK. The cholinergic hypothesis of Alzheimer’s disease: a review of progress. J Neurol Neurosurg Psychiatry. 1999 66(2): 137-47. 3- Abdel-Tawab M WO, Schubert-Zsilavecz M. Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Clin Pharmacokinet. 2011 50(6): 349-69. 4- Hussain H, Al-Harrasi A, Al-Rawahi A, Hussain J. Chemistry and biology of essential oils of genus boswellia. Evid Based Complement Alternat Med. 2013:140509. doi: 10.1155/ 2013/ 140509. 5- Moussaieff A, Mechoulam R. Boswellia resin: from religious ceremonies to medical uses a review of in‐vitro, in‐vivo and clinical trials. J Pharm Pharmacol. 2009 61(10): 1281-93. 6- Thulin M, Warfa A. The frankincense trees (Boswellia spp., Burseraceae) of northern Somalia and southern Arabia. Kew Bulletin. 1987: 487-500. 7- Sharma A, Mann A, Gajbhiye V, Kharya M. Phytochemical profile of Boswellia serrata: An overview. Pharmacog Rev. 2007 1(1): 137. 8- Poeckel D, Werz O. Boswellic acids: biological actions and molecular targets. Curr Med Chem. 2006 13(28): 3359-69. 9- Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee–A randomized double blind placebo controlled trial. Phytomedicine. 2003 10(1): 3-7. 10- Marshall S. Frankincense: festive pharmacognosy. Pharmaceutical J. 2003 271 (7280): 862-4. 11- Hosseini -Sharifabad M, Esfandiari E, Alaei H. Effects of frankincense aqueous extract during gestational period on increasing power of learning and memory in adult offsprings. Journal of Isfahan Medical School (iums). 2004 21(71): 16-20. 12- Hosseini-sharifabad M, Esfandiari E. Alaee, H. Moatar F. Effect of maternal consumption of aqueous extract of the gum resin of Boswellia serrata during lactation on increasing power of learning and memory in adult off springs. Iran J Basic Med Sci. 2003 6(3): 207-11. 13- Alaei H, Motahar F, Tory L. Effects of the abstract of oliban on learning and memory. J Ghazvin Univ Med Sci. 1999 21: 21-8. 14- Mahmoudi A, Hosseini-Sharifabad A, Monsef-Esfahani HR,et al. Evaluation of systemic administration of Boswellia papyrifera extracts on spatial memory retention in male rats. J Nat Med. 2011 65(3-4): 519-25. 15- Fathi FHH, Ali Hemmati AR, Banan Khojasteh SM. Effects of sesame oil on improving spatial memory in alzheimer's disease. J Babol Univ Med Sci. 2014 16(2): 34-41. 16- Hosseini M, Hadjzadeh MA, Derakhshan M, Havakhah S, Rassouli FB, Rakhshandeh H, Saffarzadeh F. The beneficial effects of olibanum on memory deficit induced by hypothyroidism in adult rats tested in Morris water maze. Arch Pharm Res. 2010 33(3): 463-8. 17- Hosseini M, Shafei MN, Safari V, Taiarani Z, Kafami Ladani M, Sadeghian R. The effects of olibanum administered to methimazole-treated dams during lactation on learning and memory of offspring rats. Nat Prod Res. 2012 26(16): 1544-8. 18- Hosseini-Sharifabad M, Esfandiari E. Effect of Boswellia serrata gum resin on the morphology of hippocampal CA1 pyramidal cells in aged rat. Anat Sci Int. 2014 Feb 11. [Epub ahead of print] 19- Jalili C, Salahshoor MR, Moradi S, Pourmotabbed A, Motaghi M. The therapeutic effect of the aqueous extract of boswellia serrata on the learning deficit in kindled rats. Int J Prev Med. 2014 5(5): 563-8. 20- Karima O, Riazi G, Yousefi R, Movahedi AAM. The enhancement effect of beta-boswellic acid on hippocampal neurites outgrowth and branching (an in vitro study). Neurol Sci. 2010 31(3): 315-20. 21- Lee S-C, Moon Y-S, You K-H. Effects of red ginseng saponins and nootropic drugs on impaired acquisition of ethanol-treated rats in passive avoidance performance. J Ethnopharmacol. 2000 69(1): 1-8. 22- Savelev S, Okello E, Perry N, Wilkins R, Perry E. Synergistic and antagonistic interactions of anticholinesterase terpenoids in Salvia lavandulaefolia essential oil. Pharmacol Biochem Behav. 2003 75(3): 661-8. 23- Singh G, Atal C. Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new non-steroidal anti-inflammatory agent. Agents Actions. 1986 18(3-4): 407-12. 24- Dhingra D, Parle M, Kulkarni S. Memory enhancing activity of Glycyrrhiza glabra in mice. J Ethnopharmacol. 2004 91(2): 361-5. 25- Mayford M, Kandel ER. Genetic approaches to memory storage. Trends Genet. 1999 15(11): 463-70. 26- Tully T, Bourtchouladze R, Scott R, Tallman J. Targeting the CREB pathway for memory enhancers. Nat Rev Drug Discov. 2003 2(4): 267-77.

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Type of Study: Applicable | Subject: General
Received: 2014/11/20 | Accepted: 2014/11/20 | Published: 2014/11/20

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