Search published articles


Showing 131 results for Lead

, ,
Volume 10, Issue 41 (12-2002)
Abstract


, , , ,
Volume 12, Issue 47 (6-2004)
Abstract

Background: Vaccination against hepatitis B has lead to satisfactory production of anti-HBs in more than 90% of the cases. Nevertheless, numerous studies have revealed a gradual decline in anti-HBs level. This study was carried out with the aim of determining anti-HBs serum level in 7-9 year-old children in Zanjan, vaccinated through routine nationwide vaccination program. Materials and Methods: Two hundred and seventy three students were selected through random multiple staged method from 10 elementary schools in Zanjan. After getting the letter of satisfaction from parents and preparing 5 ml blood sample, serum level of anti-HBs was determined using ELISA with Radium kit. All serums were also tested for anti-HBc. Data were categorized into four groups. The first group contained no antibody (0) the second <10, the third 10-100 and the forth >100 unit/ml and serum level under 10 was considered as weak response and confidence interval was estimated. Results: In 29.5% of the samples no anti-HBs was observed. In 22.5% the amount was under 10, in 27.5% between 10 and 100 in 20.5% over 100 unit/ml anti-HBs was detected. As a matter of fact 52% of the samples were under 10 and 48% contained over 10 unit/ml anti-HBs. Level of antibody decline in boys and girls was equal. One percent of the studied children had anti HBc. Conclusions: Decline in anti-HBs serum level was obvious five years after vaccination. However, this finding dose not either recommend or reject the administration of booster dose of vaccine. This decrease dose not imply potential for infection and it is possible that the subject would be able to produce antibody against the virus in case of exposure. More research including higher sample number is recommended.
, , , , , , , ,
Volume 12, Issue 49 (12-2004)
Abstract

Background: Spinal muscular atrophy includes a group of neuromuscular disorders characterized by degeneration of anterior horn cells in the spinal cord, and leads to progressive muscular weakness. NAIP is one of the genes that inhibits motor neuron apoptosis. Deletion of this gene is usually observed in type I SMI. The aim of this study was to investigate the frequency and pathogenicity of NAIP gene among SMA patients in east Azerbaijan and neighboring regions within the years 2004-2005. Materials and Methods: This descriptive study was carried out on 50 patients suffering from SMA by extracting DNA and molecular genetic survey of the samples. Exons 5 and 13 of NAIP gene and microsatellite D5S1416 were amplified using polymerase chain reaction (PCR) and the product on agar gel and polyacrylamid gel was put on electrophoresis through ethidium bromide stain and silver nitrate stain respectively and the frequency of different types of SMA with NAIP gene deletion was calculated. To determine the relation between gender and disease intensity test was used. Results: Out of 50 SMA patients 28% showed deletion in NAIP gene all belonging to type I of the disease with the highest disease intensity. Nine patients (64%) with deleted NAIP gene were the outcome of consanguineous marriage. Disease intensity in type I patients lacking NAIP gene was higher than type I patients with healthy genes. Conclusion: In 28 percent of patients NAIP deletion was observed. Consanguineous marriage is a promoting factor in gene mutation purification and birth of diseased neonates in studied samples. It is recommended that the families with SMA background refer to molecular genetic centers for prenatal diagnosis and close relatives avoid consanguineous marriage.


, , ,
Volume 13, Issue 50 (3-2005)
Abstract

Background and Objectives: One of the complications arising from the consumption of Cuminum Cyminum is reproductive system disorders in humans and animals. Since there has been no comprehensive research on the effect of this herbal medicine on spermatogenesis and production of testosterone in males, the present study was carried out with the aim of determining the effect of Cuminum Cyminum alcoholic extract on spermatogensis and testosterone production in adult male wistar rats in Kazeroon in 2004. Materials and Methods: In this experimental research 50 male wistar rats were divided into 5 groups of 10. Following the bioassay LD50 (lethal dose) of the compound was determined to be 120 mg/kg and concentrations of 30,60 and 100 mg/kg as sublethal doses were injected into peritoneum every other day for 21 days in three treatment groups. The two remaining groups received the solvent (distilled water) and no compound. The results were analysed through one-way analysis of variance and t-test. Results: The results showed that 100 mg/kg of Cuminum Cyminum alcoholic extract reduced serum testostrone level by 71.5% (P=0.05), while it had no significant effect on serum FSH and LH levels. Histological investigations of testis showed a decline of 19.7%, 48.3% and 89.5% sperm cells in doses 30, 60 and 100 mg/kg respectively. However, no adverse effect was observed owing to the injection. Conclusion: According to the research results it can be stated that Cuminum Cyminum alcoholic extract at 100 mg/kg of rats has probably caused the weakened function and reduced testosterone level and spermatogenesis through direct effect on testicular tissues. Research concerning the ultra structure studies of testis and the effect of the plant on hormone level in hypothalamus and fetus growth is recommended.


, , ,
Volume 13, Issue 50 (3-2005)
Abstract

Background and Objectives: Numerous studies associated with manager nurses’ conduct and empowerment of nursing staff have revealed that the managers can influence their personnel and enhance job satisfaction, commitment, responsibitity, efficiency, and service quality by impressive behavior. The goal of this study is to evaluate managerial skills retraining of manager nurses on empowerment of nursing staff in Tehran in 2004. Materials and Methods: This quasi- experimental study was carried out on 111 nursing staff. Before intervention empowerment of nursing staff was evaluated through the questionnaire whose validity and reliability had been confirmed in advance. Then the retraining program was performed for the whole nursing managers (n=20) of the hospital for 3 consecutive months. The managers were advised to use their learning in decision making policy and behavior during the training period and one month after the completion of the training, and consulting team accompanied them through the whole process. One month after completion of training period empowerment of the staff was investigated again. The data were classified and analysed through descriptive statistics (mean and standard deviation) and analytical statistics (paired t-test and analysis of regression). Results: Seventy three percent (73%) of the nursing staff had moderate ability before intervention and seventy four (74%) had moderate ability after intervention. Mean ability of the staff increased from 96.5± 18 before intervention to 106.9± 16.1 after intervention. Paired t-test indicated a significant difference in ability before and after intervention (P=0.001). Multiple step by step regression analysis showed that precursors of staff empowerment before and after intervention were morale change and healthy environment perception. Conclusion: The Study revealed that behavior change in managers led to increased skills of nursing staff. It seems that retraining programs consisting of leadership and management skills result in organizational and mental empowerment of nursing staff and improve their professional performance.


, , , ,
Volume 13, Issue 50 (3-2005)
Abstract

Background and Objectives: Stroke is the third leading cause of death in developed countries. It can also lead to a variety of neurological defects. Regarding the significance of rehabilitation in diminishing the complications, the present study was conducted to evaluate the effect of rehabilitation on life quality of patients suffering from stroke in Sahrekord in 2004. Materials and Methods: This two-step quasi - experimental study (before and after) was carried out on 30 inpatients suffering from stroke who had been selected by simple sampling and were qualified to enter the research. The data were collected using the four - domain life quality questionnaire (physical - Mental- general health and social performance) before and after intervention. To analyse the data descriptive statistics (mean and standard deviation) and analytical statistics (Paired t-test, wilcoxon and independent t-test) were used. Results: The results revealed that mean score of life quality in physical, mental, and social performance, and general health domains improved significantly following the rehabilitation measures (P=0.05). Moreover, the overall life quality increased significantly after rehabilitation compared to the period before (P=0.05). Conclusion: Rehabilitation affects different aspects of life quality positively. Establishment and strengthening the rehabilitation, educational and supportive centers provides the patients with better access to these measures and might be a step forward to their independence.


, , ,
Volume 13, Issue 50 (3-2005)
Abstract

Background and Objectives: Laparoscopic cholecystectomy as a non- invasive method in surgery is becoming common leading to brilliant results and reduction of costs. Numerous studies have investigated this method with different results. Regarding the establishment of this surgery method in Zanjan and lack of accurate data concerning the results the present study was conducted to evaluate the results of laparoscopic cholecystectomy in Zanjan during 2002-2004. Materials and Methods: This descriptive study was carried out on 79 patients suffering from biliary colic who had been selected through simple sampling. The patients underwent laparoscopic cholecystectomy and the results were investigated through indices: post operation complication rate, bed time, duration of surgery, mean peroral feeding start and conversion to open operation rate. The data were analysed through descriptive statistics. Results: The following results were obtained: mean bed time 20 hours and 40 minutes, mean time of surgery 34 minutes, mean peroral feeding start time 10.5 hours, post operation complication rate 2.5% and conversion to open operation rate 5%. Conclusion: The results of the present study are in accordance with the previous studies though the conversion to open operation rate is slightly higher. Regarding the results obtained from the research, extension of laparoscopic cholecystectomy is highly recommended in Zanjan.


, , ,
Volume 13, Issue 52 (9-2005)
Abstract

Background & Objectives: Aeromons is the cause of various infections in humans and has been isolated from different food samples and even drinking water. Research studies report the prevalence of the bacteria in diarrheic patients to be equal to or higher than shigella. Regarding the contradictory reports this study was conducted to investigate the prevalence and significance of Aeromonas in children's dysentery and their sensitivity to antibiotics in Tehran in 2003-2004. Materials & Methods: In this descrpitive study 310 stool samples of diarrheic children under 10 years of age were tested for infection to Aeromonas, plesiomonas, bacterial pathogens such as salmonella, shigella, enteropathogenic E.coli and enteric parasites and susceptibity of these agents to antibiotics was assessed through diffusion disc method on aeromonas isolates. Data were analysed using discriptive and analytical statistics (χ 2 , t-test and, Fisher exact test). Results: The results showed that Aeromonas prevalence was 4.5% and higher than salmonella and enteropathogenic E.coli in diarrheic children and it was the second leading pathogen after shigella. All Aeromonas strains were susceptible to ceftizoxime, ciprofloxacin, gentamicin and resistant to ampicillin. Conclusion: Aeromonas species are of etioloical significance in diarrheic children and they must be taken into account in bacteriologic survey of the stool samples. More research is recommended.


M Mansouri, H Navipour, R Memarian,
Volume 14, Issue 54 (3-2006)
Abstract

Background & Objective: Psoriasis is an unpredictable, chronic, cutaneous disease with recurrence period that could lead to disability and psychosis. Evidence shows that in addition to routine therapeutic procedures implementing self-care program can contribute to reduction of complications as an inexpensive method. Hence, this study was conducted with the aim of investigating the effect of self-care program on relief of the disease complications in Tehran in 2002. Materials & Methods: This quasi-experimental study (before and after) was carried out on 50 patients. Self-care program was performed in different fields (food, medicine, bathing, washing, type of clothing, temperature, …) through face to face education and role playing and the cases were investigated in terms of symptom severity (skin dryness including splitting and flaking itching and existence of new plaque) every two weeks for three months. To collect data questionnaire, self-reporting check list, observational check list with Likert scale and correlation of 92.5% were used whose validity had been confirmed through content validity. The data analysis was performed using t-test and Wilcoxon. Results: The results showed that 64% of the studied patients were male, 54% employed, 72% married and 42% had university degrees. 34% were 11-20 years old with the mean age of 11.9. The results indicated that the mean skin splitting severity decreased from 2.34 to 0.04%, flaking from 4.48 to 0.5, itching from 2.5 to 0.54 and area of lesion from 81.77 to 27.33 after intervention (P=0.0001). The comparison of behavior before and after intervention showed that the extent of all self-care behaviors increased significantly (P=0.001). Conclusion: The research results show that implementation of self-care program reduces the severity of skin symptoms. Thus, administration of this inexpensive, accessible program in care plans of patients to lower the physical, mental, familial, and social problems of patients is recommended.


A Mohammadi, Ar Shoghli,
Volume 14, Issue 54 (3-2006)
Abstract

Background & Objective: Improving quality of hospital services helps to optimize resource utilization and promotes quality of care and community satisfaction. Since identification of staff perceptions and expectations leads to increased efficiency, improvement of organization products and fulfillment of customers' present and future needs, this research was conducted in order to analyse total quality management (TQM) elements in Zanjan's hospitals from 2003 through 2004. Materials & Methods: This descriptive study was carried out on 256 employees of different hospitals in Zanjan province who had been selected through stratified random sampling. Data collecting tool was questionnaire (Likert scale) including optimal situation (expectations) and present situation (perceptions) of TQM elements which was completed by research samples. The gap between expectations and perceptions was calculated by subtracting the perceptions scores from expectations score. The results were analysed through statistical test (Kroscal-Wallis Wilcoxon). Results: The mean gap scores between optimal situation (expectations) and present situation (perceptions) were significant in all elements of TQM (P=0.01). The fair recognition and reward system was the most important dimension from employees' standpoint and scored the most negative (mean gap score= -3). Quality culture and staff empowerment were rated as the second and third most important dimensions. Conclusion: The results indicate that fair recognition and reward system, the initiative and creative culture and staff empowerment are the most important preconditions of effective implementation of TQM in hospitals. Thus, it is recommended that hospital managers establish fair reward system based on well-done performance and encourage creative work and quality culture.


R Fallah, B Falak-Ul-Aflaki,
Volume 14, Issue 55 (6-2006)
Abstract

Background & Objective: UTI is a relatively common infection of childhood which is caused by ascending colonic bacteria and is frequently seen within the first year of life. The main complicaticn of an infection is leaving a scar in kidney which can lead to renal insufficiency and hypertension. The aim of this study was to evaluate the prophylactic effect of breast feeding against UTI among children under one year of age. Materials & Methods: This case-control study was conducted on 100 children under one year of age (50 cases and 50 control). The case group was selected from patients referring to the pediatric nephrology clinic or admitted to Vali-e-Asr hospital in 2004, all of whom have suffered from UTI at least once. The children in the control group who did not experience UTI were selected from daycare centers and were alike in terms of gender, age and circumcision (in boys). The data was analyzed using chi-square and fisher's exact tests. Results: 9 (32.1%) of the children suffering from UTI and 25 (83.3%) of the healthy children had only been breast fed. The prophylactic effect of breast feeding against UTI was 90% higher in children who had only been breast fed (P=0.0005). The combined prophylactic effect of breast feeding and formula-feeding against UTI was 71% higher than only formula feeding (53.7% to 80%) (p=0.038). The preventive effect of breast feeding against UTI was higher in boys than in girls. Conclusions: This study shows that breast feeding has a prophylactic effect against UTI. We suggest that further studies should be carried out with a higher sample size to achieve comprehensive assessment.


S Sokhanvar,
Volume 14, Issue 56 (9-2006)
Abstract

Background & Objective: Patients with ischemic heart disease classified to two major groups: patients with stable angina and patients with Acute Coronary Syndrome (ACS). Previous studies showed that posterior segment of left ventricle is a silent segment on ECG, and routine 12 leads electrocardiogram (ECG) is not sensitive for evaluation of posterior infarction. This study designed for evaluation of ST segment deviation on posterior leads of ECG in patients with ACS at Beheshti hospital in 2002. Materials & Methods: This is a descriptive-analytical and prospective study. In 347 patients with diagnosis of ACS who were admitted in the emergency department, 12 leads ECG with additional three leads (V7-V8-V9) was carried out. For statistical analysis, calculation of percentages for sensitivity, odds ratios, and %95 confidence intervals was performed. Results: Major abnormalities (ST elevation 1mm and ST depression  1mm) were found on the extra three leads in %21.6 (75 out of 347). Sensitivity of ST segment elevation for acute myocardial infarction on 12 versus 15 leads increased from %68.5 to %90.7 (P=0.0005). Sensitivity of ST segment depression for acute myocardial infarction on 12 versus 15 leads increased from %31.5 to %40.7 (p=0.157). Sensitivity of ST segment elevation for unstable angina (239 cases) on 12 versus 15 leads from zero to %5 and sensitivity of ST segment depression for unstable angina on 12 versus 15 leads increased from %31.8 to %36.8 (P=0.25 ). Conclusion: The 15-leads ECG provides increased sensitivity of detecting ST–segment deviation in acute myocardial infarction and unstable angina.


H Moodi, A Akbari, F Ghiasi, Hr Mahmoudzadeh, Z Heidari, H Rashidi,
Volume 14, Issue 57 (12-2006)
Abstract

Background & objeative: Among the most common problems in patients with diabetes mellitus is the faulty healing of foot ulcer wounds which leads to foot or leg amputations. Many attempts were done to treat diabetic foot ulcers. This study evaluated the effect of vacuum-compression therapy (VCT) on healing diabetic foot ulcers. Materials & Methods: A single-blinded, randomized clinical trial was conducted in Zahedan in 2006. Twenty-two patients with diabetic foot ulcer limbs were used for this study through simple non-probability sampling. Patients were randomly assigned to either an experimental group or a control group. The surface area of the foot ulcer was measured stereologically based on Cavalieri’s Principle after 3 weeks and before any intervention. The point counting method was chosen to measure the surface area. In addition to the conventional therapy, the experimental group was also treated with vacuum-compression therapy produced by Vasotrain (VCT). The control group received conventional therapy only, which included debridement, systemic antibiotics, wound cleaning with normal-saline, and daily dressings. Independent-samples t-test and paired t-test allowed for comparisons between the pretreatment and post treatment test results between groups and within groups, respectively. Results: The mean of foot ulcer surface area decreased from 48.05±10.3 mm2 to 34.6±4.4 mm2 in experimental group (P<0.01) and also from 59.9±14.4 mm2 to 56.8±13.8 mm2 in the control group (P<0.01). The surface area of the foot ulcer in the experimental group and control group decreased by 28.4 percents and 6 percents respectively (P<0.05). After the treatment a significant decline in the surface area of the foot ulcer was observed within the experimental group in comparison to the control group (P<0.01). Conclusion: Vacuum-compression therapy enhances diabetic foot ulcer healing when used in conjunction with appropriate wound care. It is recommended that patients with diabetic foot ulcer and non-healing wounds achieve wound healing and limb preservation by using a vacuum-compression therapy.


N Ahmadbeigi Lahijani, Y Mortazavi, M Soleimani, A Omid Khoda,
Volume 15, Issue 58 (3-2007)
Abstract

Background & objective: Mesenchymal stem cells (MSCs) are presently isolated from various human tissues such as bone marrow. These cells have relatively high replication potential and can differentiate into various cell lineages with mesodermal and non-mesodermal origin and therefore, show promising in treatment of diseases. Their striking features like availability of source, ease of isolation and replication, and migration to lesions have made them appropriate for disease treatment and tissue engineering. The low frequency of MSCs in bone marrow necessitates their in-vitro expansion prior to clinical use. However, over-expansion may lead to aging or replicative senescence of MSCs and other complications for the patient. Materials & methods: In this study, we isolated BM MSCs and cultured them in vitro. After the first passage cell surface markers were determined by flowcytometry and the cells propagated in culture for more passages. Telomere length was assessed using Telo TAGGG Telomere Length Assay kit after each cell passage. Results: Our data showed that there is a direct correlation between in-vitro expansion of MSCs and reduction of telomere length. The telomere length was shortened by 1 kb after nine passages. This means that expansion induces aging through reduction of telomere length. Conclusion: These data suggest that in-vitro expansion of MSCs may restrict their future clinical application due to telomere length shortening which happens in each cell division. Thus, it would be much better to consider early passages of MSCs for cell and gene therapy due to their proliferation, differentiation and homing ability.


S Mirza-Ahmadi, S Farajnia, M Rafii, Mh Soumi, A Nakhlband, H Rezaii, L Mohammadnezhad,
Volume 15, Issue 58 (3-2007)
Abstract

Background & objective: FMF is an autosomal recessive genetic disorder characterized by acute episodes of fever accompanied by severe abdominal pain, pleurisy, arthritis, and skin rashes. Clinical symptoms of the disease vary considerably in patients, and little is known about the origin of this variation. This study investigates a male patient suffering from severe FMF and his parents. Materials & Methods: The subject was a six-month-old boy with recurrent fever accompanied by severe abdominal pain and skin rashes. Molecular screening was conducted through polymerase chain reaction (PCR) and sequencing exon10 of MEFV gene. Results: The investigation to indentify common mutations، using ARMS-PCR and exon 10 sequencing revealed an M697/M680I compound heterozygote mutation in exon 10 of the related gene. Patient′s father and mother were heterozygote for mutations M680I and M694V, respectively without having the history of FMF attacks. Conclusions: It seems that accompaniment of mutations M680I and M694V even in compound heterozygote form might lead to severe phenotype FMF. This is the first report of early onset and severe phenotype FMF case associated with a 694V/680I compound heterozygote mutation in Iran.


Mr Din Mohammadi, K Amini, Mr Yazdan Khah,
Volume 15, Issue 59 (6-2007)
Abstract

Background and objective: Opioid addiction is a major social problem among all societies worldwide. According to official reports there are about 1,200,000 chronic addicts and 800,000 recreational consumers throughout the country. One of the perplexing problems regarding addiction is its relapse since 50% of rehabilitated Iranian addicts tend to reconsumption. The aim of this study is to determine the socicl and environmental factors related to the relapse of opioid addiction. Materials and methods: In this descriptive study 96 volunteer male addicts referring to rehabilitation center of welfare organization were selected through convenient sampling. The survey tool was the questionnaire whose validity and reliability had bean confirmed before the application. Data collecting wa carried out by two trained experts through structured interview within three months. The data was analysed using SPSS -Win software. Results: The results showed that the mean age of research population was 34.66 ± 8.52. All study cases had experienced at least one attempt to quit drug use. The investigation regarding the career factor showed that they believed lack of permanent job (51%), exhausting work conditions (42.7%), failure in career achievement (41.7 %) were the leading factors in relapse of opioids substance use. The addicts reported their viewpoints regarding the other factors as follows: cost of living burden (53.1%), educational factors ( poor literacy skills (33.3%), and illiteracy (19.8%). Among familial factors in singles, lack of appropriate family relations (43.7%), and in married addicts, marital discord (22.5%), and lack of proper interaction among family members (21.2%) were the major factors. Regarding the social factors convenient availability of opioids substance (85.4%), common use of opioids in public (80.2%), and association with addicted friends (70.8%) were the leading factors. Conclusion: the study results indicated that among investigated factors, social, occupational and economic factors rank the most important factors in relapse of opioid addiction. Accordingly, a few recommendations have been given.


I Jafari Anarkooli, Ar Mahmodian, H Haghir, M Jafarpour,
Volume 15, Issue 59 (6-2007)
Abstract

Sciatic nerve, as the largest branch of the sacral plexus and the thickest nerve of the body, forms from the ::::union:::: of ventral branches of L4-S3. Then it leaves the pelvis via the greater sciatic foramen below the piriformis and descends between the greater trochanter and ischial tuberosity. Afterwards, it divides into the tibial and the common proneal nerves, most frequently at the level of the upper angle of the popliteal fossa. Bifurcation into its two major divisions may occur, anywhere, between the sacral plexus and the upper angle of the popliteal fossa. However, concurrent occurrence of these variations: dividing of the sciatic nerve into two terminal branches in pelvis, existence of piriformis with completely separated upper and lower parts, the common proneal nerve passing through the two parts of piriformis in which one part of inferior gluteal nerve fibers and tibial nerve passing under the lower part of this muscle in company with the other part of inferior gluteal nerve, is a rare and very important phenomenon. This phenomenon may be of great importance in view of both entrapment of these members between two parts of piriformis which can lead to "piriformis syndrome", and being next to the muscular injection site of the gluteal region. Furthermore, it might be of major significance for medical specialists in particular for anatomists and surgeons to reduce the postoperative complications.


J Nourooz- Zadeh, E Eftekhar, F Haghparast, Khademwatan, M Ekhlasmand,
Volume 15, Issue 60 (5-2007)
Abstract

Background and objective: Cardiovascular disease accounts for about 38% of the cause of death in Iran. The traditional risk factors can not justify the high prevalence of the disease, and therefore oxidative stress has been proposed as a contributing factor in morbidity and mortality. The aim of this study was to evaluate the plasma measures of oxidative stress in patients with CAD presented with myocardial infarction (MI) or without MI compared with the control group. Materials and Methods: This study consistsed of three groups as follow: 38 patients suffering from CAD without MI (mean age: 56.55±8.64), 20 CAD patients with MI (mean age: 50.85±7.79) and 55 healthy subjects (mean age: 49.85±8.5) as controls. Vitamin E concentration was determined through HPLC. and the amounts of glutathione and malondialdehyde were measured by spectrophotometer. Results: Plasma malondialdehyde levels were markedly higher in patient groups than in control groups (P<0.05). Lower glutathione levels were observed in patient groups compared with control group, whereas, reduced Vitamin E was only noted in CAD patients without MI (P<0.05). No significant differences were seen between measures of oxidative stress in patient groups. Conclusion: Reduction of glutathione molecules as antioxidants and enhanced lipid peroxidation may be involved in pathogenesis of CAD through up-regulation of signaling pathways leading to tissue damage.


R Ghaderi, T Kazemi, A Zarban, M Erfanian,
Volume 15, Issue 60 (5-2007)
Abstract

Background and Objective: Evidences shows that the defect in the synthesis of some fatty acids can lead to seborrheic dermatitis and elevated serum lipids in lipophilic fungi activities. Epidemiologic reports suggest a relationship between antioxidant levels and serum liplds in a number of dermatitis. This study was carried out to determine the relationship between antioxidant levels of plasma and serum lipids with seborrheic dermatitis. Methods and Materials: In this case-control study 70 patients suffering from SD were compared with 70 healthy people as control group. The two groups had been matched in terms of age and sex. Lipid levels and plasma antioxidants were measured by FRAP ( Ferric Reducing A Bility Of Plasma Assay ) in both groups. In patients skin lesions samples were tested through web spread to confirm the diagnosis and severity of pityrosporum ovale. The collected data was analyzed by SPSS software, T-Test and Chi-Square tests. Results: The mean level of cholesterol in treatment group (120.5+39.9 mg/dl) was higher than control group (166.5+39.1 mg/dl) and the mean triglyceride level in treatment group (138.1+65.3 mg/dl) was higher than control group (91.7+44.2 mg/dl), which were both statistically significant (p<0.001). No significant difference was observed between HDL cholesterol in treatment and control groups (p<0.177). However, the mean LDL level was higher in treatment group (143.5+37.6 mg/dl) than that of control group (106.3+35.6 mg/dl) which shows a significant difference (p<0.001). No significant difference was observed between the mean plasma antioxidants in treatment and control groups (p>0.05). Conclusion: The study findings suggest the relationship between SD with total cholesterol and triglyceride levels and blood plasma LDL. However, there was no association between SD and plasma antioxidant and HDL levels.


M Hashemitabar, M Orazizadeh, Ls Khorsandi,
Volume 16, Issue 62 (3-2008)
Abstract

Background and Objectives: Apoptosis (programmed cell death) is an important regulatory event in spermatogenesis. Abnormally accelerated apoptosis in germ cells, may lead to an imbalance between cell proliferation and death, resulting in impairment in spermatogenic. Some studies have shown that glucocorticoids affect testialar homeostasis by decreasing of testosterone level. In the present study, the influence of dexametasone (Dex), a widely used glucocorticoid agent, on expression of FasL (Fas-Ligand) protein (a proapoptotic protein) in mouse testicular germ cells is investigated. Materials and Methods: Twenty-four adult male (6- 8 weeks) mice were randomly divided into 3 groups. The first and second test groups received 2 and 7 mg/kg Dex per day, respectively, for 7 days. The control group received only saline daily for 7 days. One day after the final injection, the mice were sacrificed and the test groups were placed in formalin solution for immunohistochemistry studies. Positive immunoreactivity was calculated by H-score method. Results: The results revealed that expression of FasL in seminiferous epithelium is spermatogenic stage dependent, and the stage VII was the most susceptible to Dex. FasL expression was observed only at stages VII-VIII of spermatogenic cycle in 2 mg/kg Dex treated group (P<0.05). H-score was significantly increased in all stages of 7 mg/kg Dex treated group (P<0.05). The number of spermatocytes decreased significanhy in this group. Conclusions: It appears that glucocorticoid agents such as Dex, induces apoptosis by affecting proapoptotic proteins.



Page 1 from 7    
First
Previous
1
 

© 2019 All Rights Reserved | J Adv Med Biomed Res

Designed & Developed by : Yektaweb  Co-Publisher: Farname Inc.