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Showing 4 results for خزاعی

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Volume 1, Issue 3 (6-1993)

Sh Madani, E Javadi Rad, S Khazaei,
Volume 17, Issue 69 (12-2009)

Background and objectives: Uterine smooth muscle tumors are the most common human neoplasms. They are divided clinically as benign and malignant but there is another group of lesions which is difficult to place in these two categories, so-called (STUMP) and differentiation of these tumors on the basis of H&E staining is impossible. The aim of this study was to find a set of distinguishing objective biomarkers and a survey of immunohistochemical (IHC) markers comparing these three groups of tumors. Materials and Methods: Twenty one (21) cases in each group of the above mentioned tumors were randomly selected (63 cases in total ) from pathobiology laboratories of Kermanshah and Shiraz cities and studied by IHC for expression of ER, PR, C-kit, Bcl-2, P16, and P53 . Results: The frequency of IHC markers expression in leiomyosarcoma (LMS) were as follow: ER (5.26%), PR (15.52%), P53 (26.31%), Bcl-2 (15.78%), C-kit (15.52%) and P16 (15.42%). In the STUMP cases: PR (23.80%), Bcl-2 (4.76%) and P16 (9.52%), ER, C-kit and P53 were not expressed. In Leiomyoma group, only Bcl-2 was expressed (14.28%) and the others had no expression. P53 and P16 expression between the two groups of Leiomyoma and LMS, and also STUMP and LMS were significantly different (P<0.05). Conclusion: P53 and P16 are reliable markers for differentiation between STUMP and LMS and also Leiomyoma from LMS and have a high diagnostic specificity. STUMP is used to identify cases in which clinicopathologic findings for final diagnosis as benign or malignant is not adequate. In this study a high similarity of STUMP group of immunohistochemical profile with benign cases was seen.

S Rajaie, L Azadbakht, P Saneei, M Hkazaei, A Esmaeilzadeh,
Volume 20, Issue 83 (8-2012)

Background and Objective: Dietary carbohydrate restriction is one of the most effective approaches in the management of metabolic syndrome. However, there is little information available on the role of inflammatory processes. Materials and Methods: In a randomized cross-over clinical trial, thirty overweight or obese (BMI>25 kg/m2) women with metabolic syndrome were randomly allocated into two groups, to follow either a high-carbohydrate (HC) (60-65% carbohydrates, 20-25% fats) or a moderately-restricted carbohydrate (MRC) (43-47% carbohydrate, 36-40% fats) diet for 6 weeks. After a 2-week washout period, individuals were switched to the alternate diet for an additional 6 week period. At the beginning and the bend of each period, markers of inflammation (hs-CRP, hs IL-6, hs TNF-α and SAA), endothelial function (E-selectin, sICAM-1 and sVCAM-1), and adipocytokines (leptin and adiponectin) were measured in both study groups at baselines (i.e., fasting state). Results: Consumption of the HC diet was associated with increased levels of SAA (3.27 ±1.22 μg/ml), while consumption of MRC diet did not result in such unfavorable effects (P=0.04). Serum concentrations of leptin and adiponectin were reduced by the HC diet (P<0.02), but these changes were not significant between the two diets (P>0.05). Serum concentrations of hs-CRP, hs TNF-α and IL-6 were not influenced by either diet. There were also no significant differences observed between the two diets in terms of their effects on serum sICAM-1, sVCAM-1, and E-selectin concentrations. Conclusion: Short-term substitution of dietary carbohydrates by unsaturated fats seems to have no significant effects on serum levels of adipocytokines, biomarkers of inflammation, and endothelial function except for SAA.

E Ghanbari, A Ansarian, F Yosefzaei, M Khazaei,
Volume 25, Issue 111 (6-2017)

Background and Objective: Diabetes mellitus is one of the most common metabolic disorders worldwide. Numerous natural compounds have been developed to treat diabetes mellitus. Royal jelly (RJ) has antioxidant and antidiabetic properties. This study was carried out to investigate the effects of RJ on antioxidant status, lipid peroxidation and liver tissue in diabetic rats.

Materials and Methods: In this experimental study, 32 adult male Wistar rats (190-200 gr) were randomly divided into 4 groups including control, royal jelly, diabetic and diabetic treated with royal jelly. Diabetes was induced by intraperitoneal injection of streptozotocin (50 mg/kg) and Royal Jelly (100 mg/kg) was gavaged for 42 days. At the end of our study, serum levels of malondialdehyde, total antioxidant capacity (TCA) and superoxide dismutase/glutathione peroxidase activity were determined spectrophotometrically, while the rat’s livers were isolated for histological study.

Results: Consumption of RJ showed a significant decrease in malondialdehyde serum levels (P= 0.007) and a significant increase in total antioxidant capacity, superoxide dismutase (P=0.0019) and glutathione peroxidase activity in the RJ treated diabetic rats compared to diabetic rats (P= 0.003). Administration of royal jelly improved liver histological states.

Conclusion: RJ increases antioxidant power and prevents the occurrence of histopathological changes resulting from diabetes in rats.

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