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Showing 9 results for داداشی

M Mohseni, K Dadashi, A Heidari,
Volume 23, Issue 100 (7-2015)
Abstract

Background and Objective: With the industrialization of nanotechnology and increase in application of nanoparticles in modern technology, carrying out research on nanoparticles and their effects on health is necessary. So, this study was aimed to assess acute toxicity of molybdenum nanoparticles on serum biochemical function of kidney in rat.

Materials and Methods: In this experimental study, 24 male rats were randomly divided into four groups of six: a control group and tree treatment groups. The control group received 1 ml distilled water and the treatment groups received intraperitoneal injection of 5, 10 and 15 mg/kg of molybdenum nanoparticles of 10 nm daily for 28 days. After the last dose, blood samples were taken from all groups and levels of Blood Urea Nitrogen (BUN), creatinine, total protein and albumin were measured and then the groups were compared.

Results: The serum levels of BUN and creatinine in the group receiving 15 mg/kg dose decreased significantly compared to the control group (P<0.05). The serum albumin level in the groups receiving 10 and 15 mg/kg doses showed significant decrease compared to the control group (P<0.05). The serum total protein level in the groups receiving 5, 10 and 15 mg/kg doses showed significant decrease compared to the control group (P<0.05).

Conclusion: The results of this study showed that molybdenum nanoparticles of 10 nm at these concentrations decrease creatinine and BUN levels of serum.


M Khani, M Dadashi, A Ghoreishi,
Volume 25, Issue 111 (6-2017)
Abstract

Background and Objective: Cognitive and physiological components such as intolerance of uncertainty, cognitive avoidance and brain/behavior systems have a significant impact on generalized anxiety disorder. The mentioned components are considered as the main causes of the emergence and persistence of this disorder. The aim of this study was to compare brain/behavioral system activity, intolerance of uncertainty and cognitive avoidance among individuals with generalized anxiety disorder and normal people.

Materials and Methods: The participants of this study were randomly chosen from Zanjan University students and were composed of two major groups of 45 patients with generalized anxiety disorder and 45 normal individuals. Short scale generalized anxiety disorder (GAD-7), Gray-Wilson Personality Questionnaire (GWPQ), intolerance of uncertainty scale (IUS) and cognitive avoidance questionnaire (CAQ) were given to the subjects. Later, those who had scored higher on the short scale generalized anxiety disorder (GAD-7) and were diagnosed with generalized anxiety disorder using a structured clinical diagnostic interview based on DSM (SCID-I) were categorized as diagnosed with GAD. The normal individuals group consisted of those who were not diagnosed with any kind of mental disorder using a structured clinical diagnostic interview based on DSM (SCID-I). Data analysis was performed using multivariate analysis of variance (MANOVA) and regression analysis.

Results: Between cognitive components, intolerance of uncertainty in the group with generalized anxiety disorder was significantly higher than the normal group (p< 0/05). Between physiological parameters, a subscale of behavioral inhibition system in individuals with generalized anxiety disorder was significantly higher than the normal group (p< 0/05).

Conclusion: Intolerance of uncertainty and behavioral inhibition system proved to be good parameters for the prediction of generalized anxiety disorder. Furthermore, the intolerance of uncertainty, behavioral inhibition system, and behavioral activation system were different in patients with generalized anxiety disorder and normal individuals.


M Dadashi, S Bastami, Z Eskandari,
Volume 25, Issue 112 (7-2017)
Abstract

Background and Objective: Among the most challenging component of addiction are the craving and the cues related to the drug abuse which have made the treatment actions ineffective, thus resulting relaps. The aim of this study is to examine the effectivness of anodal transcranial direct current stimulation(tDCS) over left dorsolateral prefrontal cortex on drug craving and attentional bias  symptoms in opium addictied males.

Materials and Methods: This was a Quasi-experimental work with pretest-posttest design. 44 patients were selected through convenient sampling and were randomly assigned into two exprimental and control groups. Before the treatment, both groups were tested through craving questionnaire and cmputerized emotional stroop test.The experimental group received a 20 minute electrical stimulation of the brain by stimulator with the intensity of 2 mA for 10 sessions. Aa the end, both groups were tested through craving questionnaire and cmputerized emotional stroop test and the data were analysed with MANCOVA and ANCOVA.

Results: The results showed that tDCS anodic left dorsolateral prefrontal cortex decreased craving level and reduced attentional bias in the experimental group compared to the control group in opium addicted males. (p<0/001). There was a significant difference between control and experimental groups.

Conclusion: The findings of this study could have important implications as regards drug craving reduction and attentional bias improvement in opium addicted males. Therefore,this treatment could be utilized in clinics for opium addicted males.


V Yousefi Asl , Y Morsali, M Dadashi,
Volume 26, Issue 114 (3-2018)
Abstract

Background and Objective: Obsessive-compulsive disorder (OCD) is a mental dysfunction. The main characteristics of OCD are serious and continuous mental and functional obsessions that severely inflict patients. The purpose of this study was to assess the effectiveness of exposure and response prevention (ERP) versus transcranial direct current stimulation (tDCS) in reduction of anxiety symptoms and increase of global functioning in patients with OCD.
Materials and Methods: This study employed clinical trial with pre-post tests and follow-up. 20 patients with OCD who had referred to psychology and psychiatry clinic of Shahid Beheshti Hospital in Zanjan, were selected according to purposive sampling and were randomly assigned to two treatment groups. Throughout the baseline, post-treatment and follow-up (one month and two months after the treatment), the subjects were asked to complete Beck Anxiety Inventory (BAI) questioner. Global Assessment of functioning (GAFS) was also employed to evaluate global functioning. Eventually, the collected data was analyzed using SPSS (version 20).
Results: The results indicated that there was no considerable differences between the two groups regarding anxiety symptoms in the post-test, but there was significant differences in global functioning between ERP and tDCS.
Conclusion: The findings confirmed that both ERP and tDCS methods with pharmacotherapy were considerably effective in the reduction of anxiety signs and symptoms and the increase of global functioning in patients with OCD, but the effectiveness of ERP was clinically more significant than tDCS.
M Dadashi, S Momtazi, V Yousefi Asl, B Gharaei, A Asghar Nejad,
Volume 26, Issue 115 (5-2018)
Abstract

Background and Objective: The Post traumatic stress disorder (PTSD) is an acute psychological reaction to severe traumatic events. Non-pharmacological treatments are considered as the first line treatment for PTSD and should be basically complementary to the treatment plans for patients with PTSD. However, some patients do not respond adequately to non-pharmacological treatments. The purpose of this study was to compare the efficiency and effectiveness of drug combination with meta-cognitive and drug therapy alone in reducing the severity and symptoms of PTSD.
Materials and Methods: The samples of this study were the people who referred to the Shahid Beheshti Hospital of Zanjan, Iran. The type of clinical trial was single case and multiple baseline type. Six male subjects were selected by available sampling method and were then randomly assigned to two groups. The subjects in  the pre-treatment stage (baseline) and during the fourth, eighth and post-treatment sessions, as well as follow-up (1 month and 2 months) and after the treatment and follow up (1 month and 2 months), completed the questionnaires of Clinical Executive Scale for post-traumatic stress disorder (CAAI), Beck anxiety (BAI), negative meta-cognitive (MCQ-30), SUDS and Function Psychology (GAFS).
Results: The results showed that both methods (combination of drug therapy with meta-cognitive therapy) were effective in the treatment of post-traumatic stress disorder and this effect was higher in the first method (combination of drug therapy with meta-cognitive therapy).
Conclusion: The results of this study indicate that both methods (Combination of drug therapy with meta-cognitive therapy) were effective in reducing symptoms and anxiety symptoms in patients with PTSD than drug therapy alone. Also, combination therapy reduces the amount of discomfort and improves overall performance of the patients
 
 
A Hemmat, M Dadashi, S Momtazi, S Zenoozian, J Mohammadi Bytamar,
Volume 26, Issue 116 (7-2018)
Abstract

Background and Objective: Today in the third wave of psychotherapy, it is claimed that individuals with cognitive flexibility, awareness, and acceptance of thoughts can modify their feelings and behaviors. The purpose of this study was to determine the effectiveness of group therapy based on acceptance and commitment in the reduction of craving and the improvement of quality of life in addicts receiving methadone treatment.
Materials and Methods: In this quasi-experimental study, the statistical population includes all male addicts receiving methadone treatment in Zanjan in 2015-2016. A sample of 30 subjects was selected through convenience sampling and later they were randomly assigned to intervention and control groups. The intervention group participated in 8 sessions of 90-minutes group therapy based on acceptance and commitment.  Craving questionnaires of Franken et al. (2002) and quality of life (SF-36) were conducted in the form of pre-test, post-test and a quarterly follow-up period in both groups.
Results: Group therapy based on acceptance and commitment could effectively reduce craving and increase mental health (P <0.05). The effectiveness of this intervention in increasing physical health was not statistically significant (P> 0.05). The effects of group therapy based on acceptance and commitment on post-test craving and mental health in quality of life were significant in comparison to the control group and these effects remained stable over a quarterly follow-up period.
Conclusion: The present study showed that acceptance and commitment therapy is effective in decreasing craving and improving mental health.
 

 
 
Ehteshami Pouya S, Momtazi S, Makri A, Eskandari Z, Dadashi M,
Volume 26, Issue 117 (9-2018)
Abstract

Background and Objective: Amphetamine abuse has become a major problem in recent years. The aim of this study was to examine the efficacy of Matrix Model treatment in  amphetamine abusers.
Materials and Methods: This study was a clinical trial with a pretest-posttest design. The study population included all known abusers of amphetamines in Zanjan, Iran.The sample consisted of 40 people referring to local psychiatric and psychological clinics. They were chosen based on convenient sampling and were randomly assigned into two groups, pharmacotherapy and combined therapy (pharmacotherapy and Matrix Model treatment). ASI questionnaires and urinary tests were administered before and after treatment and the data were analyzed using ANCOVA and chi-squared tests.
Results: The treatment was effective when considering job status, drug and alcohol abuse, salary, family and mental status (p= 0/001). In terms of the medical status of addiction severity, there was no significant difference between the two groups. Chi test showed that the frequency of positive urinary tests decreased in the combined therapy group (p= 0/05).
Conclusion: Results suggest that the Matrix Model Treatment can reduce addiction severity and can also reduce the frequency of positive urinary tests.
 

 
Dadashi M, Taremian F, Momtazi S, Khani M, Eskandari Z, Armani Kian A, Birashk B,
Volume 26, Issue 117 (9-2018)
Abstract

Background and Objective: Generalized Anxiety Disorder (GAD) is one of the most common psychological disorders characterized by excessive and uncontrollable worry and it has ahigh comorbidity with other anxiety disorders and depression. The aim of this study was to compare the efficacy of metacognitive therapy (MCT), pharmacotherapy and neurofeedback treatment in treating Iranian patients with GAD.
Methods and Materials: 42 outpatients meeting DSM-5 criteria for GAD who had been referred to Sohravardi clinical psychology and psychiatry center in the city of  Zanjan were chosen on the basis of convenient sampling and were randomly assigned into three treatment groups: metacognitive therapy (n=14), pharmacotherapy (n=14) and neurofeedback treatment (n=14). All patients in each group were treated for 8 weeks. The General Anxiety Disorder Scale (GAD-7) was administered blindly Pre and Post intervention.Alpha brain waves in the occipital area (O1 and O2) using neurofeedback (pro-comp-5) were registered Pretest and Posttest. Throughout the research, 36 patients remained in the study while 6 patients forfeited. The results were analyzed using ANCOVA, ANOVA, Kolmogorov–Smirnov test, ANOVA with repeated measures and post hoc test.
Results: The ANCOVA and post hoc results showed that neurofeedback, MCT and pharmacotherapy led to significant improvements in GAD-7. Also regarding alpha amplitude enhancement, the results indicated that neurofeedback led to a more significant increase when compared to MCT and pharmacotherapy.
Conclusion: It seems that neurofeedback is more effective than MCT and pharmacotherapy for the treatment of GAD and the results of this study confirm the effectiveness of O1-O2 protocol (alpha brain wave amplitude increase) in GAD symptoms severity improvement.
 
 
 
Hemmat A, Mohammadi Bytamar J, Pirzeh R, Dadashi M,
Volume 26, Issue 117 (9-2018)
Abstract

Background and Objective: The third wave of cognitive behavioral therapy (CBT) including acceptance and commitment therapy (ACT) embraces new approaches and methods potentially capable of addressing complex cases of substance abuse. It seems that the third wave of (CBT) emphasizing mindfulness and psychological resilience are effective in the rehabilitation of addicts undergoing methadone treatment.The present study intended to assess the effectiveness of group therapy based on acceptance and commitment in reducing the obsessive-compulsive use of substance, anxiety and depression of addicts under methadone treatment.
Materials and Methods: In this quasi-experimental study, the statistical population included all addicted men who received methadone treatment in Zanjan in 1983-94. A sample of 30 patients was selected through convenience sampling & randomly assigned into two groups, intervention and control. The intervention group participated in 8 sessions of 90-minute group therapy based on acceptance and commitment. Obsessive-compulsive use of substance and anxiety/depression questionnaires were completed in the form of a pre-test, a post-test and a quarterly follow-up period in both groups.
Results: Group therapy based on acceptance and commitment effectively reduced the obsessive-compulsive use of substance, anxiety and depression (P <0.05).The effectiveness of this intervention in increasing physical health was not statistically significant (P> 0.05). The effect of group therapy based on acceptance and commitment was substantial in comparison to the control group in the post-test phase regarding the obsessive-compulsive use of substance (1.04), anxiety (1.63) and depression (1.6), furthermore, these effects remained stable over a quarterly follow-up period.
Conclusion: The present study showed that acceptance and commitment therapy is effective in decreasing obsessive-compulsive use of substance, anxiety and depression.Therefore, acceptance and commitment therapy can be used as an effective intervention for psychological disorders associated with drug abuse in methadone-treated patients.
 
 

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