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S Darabian, S Rezaie, P Kordbachche, Mr Safari,
Volume 19, Issue 74 (3-2011)

Background and Objectivs: Trichophyton rubrum is considered as the most common causes of dermatophytosis in human skin and nail tissues. Microsporeum canis is a zoophile dermatophyte which can be transmited to human. HSP70 is a 70 KD heat shock protein in fungi. In this study, the effects of variable CO2 concentrations were examined on HSP70 expression in T. rubrum and M. canis. Materials and Methods: Strains used in this study were obtained from skin scales and nails of the patients who were suffering from onychomycosis. Samples were cultured on Sabouraud dextrose broth (SDB) and incubated at 25°C for 2, 4 and 7 days under 3%, 5%, and 10% of CO2 concentrations. Control cultures maintained for 7 days without CO2 concentrations. Then, RNA was isolated from the harvested mycelia mass, and HSP70 gene expression was studied in T. rubrum and M. canis by RT-PCR. The obtained results were compared to the Beta actin as a house keeping gene. Results: The results of this study revealed the maximum variations under 3%,5%, and 10% of CO2 concentrations in maximum 7 days incubation period, and the expression of HSP70 gene showed different variations under different CO2 concentrations. Conclusion: Our results showed a negative effect of CO2 concentrations in the expression of HSP70 in T. Rubrum and a positive effect in M. canis comparing to the controls.

I Rahimian Boogar, Ma Besharat, M Darabian,
Volume 20, Issue 82 (7-2012)

Background and Objective: Atrial fibrillation is the most prevalent arrhythmia, accompanied with some adverse complications, after coronary artery bypass graft surgery. The purpose of this study was to investigate the role of psychological risk factors, as well as age and gender for the incidence of atrial fibrillation after coronary artery bypass graft surgery. Materials and Methods: In this retrospective cross-sectional survey, a total of 317 patients, whom undergone coronary artery bypass graft surgery in the Tehran Heart Center and Tehran Cardiac Surgery Center of Bo-Ali Hospital were selected by convenience sampling. Among these cases, following the coronary artery bypass graft surgery, 89 (28.1%) of them had atrial fibrillation. Data were collected by demographical questionnaire and Depression Anxiety Stress Scales (DASS) and analyzed by chi-square, independent t-test with binary Logistic Regression using the PASW software. Results: Depression (OR= 4.57), stress (OR= 4.49), anxiety (OR= 3.61), age (OR= 4.77), and gender (OR= 2.38) could significantly differentiate the patients with atrial fibrillation from those without it after the bypass surgery (P<0.0001). The total regression model explained that 97.2% of this sample was classified correctly (P<0.05). Conclusion: Depression, stress, and anxiety as psychological risk factors, and age and gender, as background risk factors, all appear to contribute in the incidence atrial fibrillation after coronary artery bypass graft surgery. These results might have applicable implications in prevention of atrial fibrillation after the bypass surgery and its related adverse complications.

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