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Showing 4 results for قدرتی

S Ghodrati, Sn Mousavinasab, B Pezeshki, A Hormati,
Volume 19, Issue 76 (5-2011)

Background and Objective: Asthma is one of the most common chronic diseases that in some cases it is manifested as chronic coughs without any other symptoms. Cough variant asthma (CVA) is an occult form of asthma of which, the only sign or symptom is chronic cough and therefore should always be considered in the differential diagnosis of chronic coughs. The aim of the present study was to detect the prevalence of cough variant asthma (CVA) among patients with chronic and persistent coughs. Materials and Methods: This study was performed in the respiratory outpatient clinic at Vali-e Asr Hospital of Zanjan, Iran, during 2009. Methacholine challenge test was carried out in 92 patients suffering from chronic coughs. CVA was diagnosed as chronic coughs without wheezing or any apparent cause which had persisted for more than 8 weeks, with a normal CXR and spirometry but with bronchial hyper-responsiveness to methacholine, based on % 20 drop in FEV1 before and after methacholine challenge test. Results: Of the 92 patients suffering from chronic cough, 24 patients (%26.1) satisfied the criteria for CVA and had positive methacholine challenge test. There was a significant association between patients' job (P=0.003) and education (P=0.001) and positive test. Conclusions: These findings suggest that CVA is a common etiology for chronic cough and its early diagnosis and treatment is significantly important to prevent progression of the disease to classic asthma.

S Ghodrati, A Hormati, Sn Mousavinasab, M Afifian,
Volume 19, Issue 77 (6-2011)

Background and Objective: Asthma is one of the most common chronic diseases with an increasing prevalence. The cough variant of asthma (CVA) is a latent form of the disease. The aim of this study is to compare the decreasing rates of FEV1 and PEF during the methacholine challenge test. Materials and Methods: In this study, we tested a total of 120 patients (14-65 years old), whom were referred to the respiratory clinic with complaints of chronic cough, using normal chest and sinus x-ray and spirometry. Also other causes of chronic cough were rulled out. Spirometry and Peak Flowmetry were done during the methacholine challenge test, then FEV1 and PEF were recorded. Results: From 120 patients, 47 patients (39.2%) were male and 73 (60.8%) were female. Thirty three (27.5%) patients showed a ≥ 20% decrease in FEV1, while 35 patients (29.2%) had a ≥ 20% decrease in PEFp. Decreasing values of FEV1 and PEFp with r=0.49 and P-value<0.0001 were significant. Normalization for age, sex, and occupation shows that these factors have no effects on the decrease observed for FEV1 and PEFp. Conclusion: Based on the correlation ratio for PEFp in comparison with spirometry’s FEV1, we suggest using peak flowmetry instead of spirometry for diagnosing CVA. According on the ROC_curve, we recommend a ≥ 15.5% decrease in the level of PEFp with 79% sensitivity and 69% specificity.

S Ghodrati, M Ashrafi, H Chiti, Sn Mousavinasab,
Volume 22, Issue 93 (6-2014)

Background and Objective: COPD is one of the most common causes of death in the world. Metabolic syndrome is a pro-inflammatory and pro-coagulatory condition and a collection of cardiovascular factors, hypertension and dyslipidemia have increasing effects on morbidity and mortality and attacks of COPD disease. The aim of this study was to evaluate the relationship between metabolic syndrome and COPD. Materials and Methods: This case- control study included 76 COPD patients who had referrred to Valiasr Hospital of Zanjan and 76 non-COPD patients. Metabolic syndrome criteria was evaluated based on NCEP-ATP III and data was analyzed with T-test,Chi2 –test, Fisher exact test and logistic regression. SPSS 16 was used for data analysis. Results: The two groups had no differences in age and sex. The mean age in the case group was 63.3± 11.1 and in the control group was 60.6± 9.5. The age range of the participants was between 40 to 84 years. Prevalence of metabolic syndrome based on NCEP-ATP III, was 31.5% (24 persons) in the case group and 26.3% (20 persons) in the control group. With logistic regression analysis there was a significant difference between the two groups (p= 0.017). Occurrence of metabolic syndrome had no significant relationship with severity of COPD disease (p=0.27) and prevalence of this syndrome in COPD patients according to severity was: I: 37.5% II: 20% III: 45% and IV: 30%. Concerning the criteria of metabolic syndrome, hypertension had the most important relationship with COPD. Abdominal obesity, hypertension and HDL abnormality sequentially were the most common criteria of metabolic syndrome in patients with this disease. Also, this study pointed out that the risk of acquiring metabolic syndrome in females was more than males (P=0.01) Conclusion: Due to high prevalence of metabolic syndrome in COPD patients, some measures must be taken to prevent non-correctable metabolic indices. Rapid diagnosis and treatment of effective risk factors for COPD progression, specially in females should be considered.

Mr Jamshidi, F Qatreh Samany, G Goli Farhood, S Qodrati, B Falakaflaki,
Volume 24, Issue 105 (6-2016)

Background and Objective: Ventilator-associated pneumonia is a common infection in intensive care units leading to increased morbidity and mortality. This study was conducted to examine the effects of mechanical (tooth brushing), pharmacological (topical oral chlorhexidine), and their combination (tooth brushing plus chlorhexidine) in oral care on preventing the ventilator-associated pneumonia of critically ill patients in intensive care units.

Materials and Methods: Patients admitted to intensive care units of Ayatollah Mousavi Hospital of Zanjan that received intubation within 24 hours were considered as subjects of this study.  The patients (n= 180) were randomly allocated to three groups: first group (n=60) was administered 0.12% solution of chlorhexidine oral swab; second group (n=61) used tooth brushing; third group (n=59) used both tooth brushing and chlorhexidine oral swab. Ventilator-associated pneumonia was determined by using the Clinical Pulmonary Infection Score.

Results: The three groups did not differ significantly in clinical characteristics. At days 3 and 7, pneumonia developed in 29.4% and 59.4% of patients, respectively. The frequency of pneumonia at days 3 and 7 was not different in three groups.

Conclusion: Mechanical and pharmacological or their combination in oral care did not point to any kind of superiority of one approach over another in terms of the prevention of ventilator-associated pneumonia.

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