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Showing 5 results for Jafari Anarkooli

I Jafari Anarkooli, Ar Mahmodian, H Haghir, M Jafarpour,
Volume 15, Issue 59 (6-2007)

Sciatic nerve, as the largest branch of the sacral plexus and the thickest nerve of the body, forms from the ::::union:::: of ventral branches of L4-S3. Then it leaves the pelvis via the greater sciatic foramen below the piriformis and descends between the greater trochanter and ischial tuberosity. Afterwards, it divides into the tibial and the common proneal nerves, most frequently at the level of the upper angle of the popliteal fossa. Bifurcation into its two major divisions may occur, anywhere, between the sacral plexus and the upper angle of the popliteal fossa. However, concurrent occurrence of these variations: dividing of the sciatic nerve into two terminal branches in pelvis, existence of piriformis with completely separated upper and lower parts, the common proneal nerve passing through the two parts of piriformis in which one part of inferior gluteal nerve fibers and tibial nerve passing under the lower part of this muscle in company with the other part of inferior gluteal nerve, is a rare and very important phenomenon. This phenomenon may be of great importance in view of both entrapment of these members between two parts of piriformis which can lead to "piriformis syndrome", and being next to the muscular injection site of the gluteal region. Furthermore, it might be of major significance for medical specialists in particular for anatomists and surgeons to reduce the postoperative complications.

I Jafari Anarkooli, M Sankian, Sh Ahmadpour, H Haghir, Sh Bonakdaran, A Varasteh,
Volume 15, Issue 60 (5-2007)

Background and objective: Diabetes is a metabolic disorder that has been shown to adversely affect both the central and peripheral nervous system by increasing basal neuronal apoptosis. Since Bcl-2 protein family is considered to play a key role in the regulation of apoptosis, in the present study we have examined the effects of insulin and ascorbic acid on expression of Bcl-2 family members including Bax (pro-apoptotic) and Bcl-2 and Bcl-xL (anti-apoptotic) on hippocampus of STZ-induced diabetic rats. Materials and Methods: Five groups of six Wistar rats including one control group (C) and four diabetic groups (D, I, AA and I+AA) were used in this study. Diabetes was induced by injection of 60 mg/kg STZ (IP). After six weeks, rats in group I were treated with insulin (4-6 U/kg/day Sc), rats in group AA were treated with ascorbic acid (200 mg/kg/day IP) and rats in group I+AA were treated with equal dosage of both insulin and ascorbic acid for two weeks. Rats in group D were treated with normal saline and considered as diabetic control group. Two weeks after treatment, expression of Bcl-2, Bcl-xL and Bax genes were measured at both mRNA and protein levels. Results: In diabetic control rats (group D), Bax increased whereas Bcl-2 and Bcl-xL decreased at both mRNA and protein levels compared to group C (P<0.01, P<0.001 respectively). Interestingly, treatment with insulin (group I), ascorbic acid (group AA) and insulin plus ascorbic acid (group I+AA) could reverse these changes both at mRNA and protein levels (p<0.001 for I and AA+I groups, p<0.05 (Bcl-2) and p<0.01 (Bcl-xL) for AA group). Conclusion: It is concluded that insulin and ascorbic acid alone or together can inhibit apoptosis in STZ-induced diabetic rats' hippocampus through increasing the ratio of Bcl-2/Bax and Bcl-xL/Bax expressions. We suggest that inhibition of apoptosis may prevent cognitive dysfunctions induced by hippocampal damage in diabetic patients as well. In addition, further experimental studies will need to be performed to confirm such effects.

Mohsen Alipour, Davood Sohrabi, Mohammad Reza Gholami, Iraj Jafari Anarkooli,
Volume 19, Issue 77 (6-2011)

Background and Objective: Ischemia reperfusion plays a major role in the development of pathological alterations in many different neuropathies. In this study, we evaluated the role of aminoguanidine (AG) in the functional recovery of the rat re-perfused sciatic nerve based on the behavioral scores.
Materials and Methods: Seventy two rats were divided into 12 groups (n = 6). We used ischemic model by occluding the right common iliac and femoral arteries for 3 h with a silk suture 6-0 using the slipknot technique. Treatment groups (2, 4, 6, 8, 10 and 12) received 150 mg/kg of AG intraperitoneally 24 hrs after the induction of ischemia. After certain time intervals of reperfusion (48 hr, and 4, 7, 14, and 28 days), the function of the hind limb was assessed using behavioral scores based on gait, racing reflex, toe spread, pinch sensitivity, paw position ,and grasp.
Results: Hind limb functional deficits developed in all reperfused groups, and maximal behavioral deficit occurred on day 7 of reperfusion. The comparison of the control and AG groups revealed a better time course in recovery and improvement of the behavioral score.
Conclusion: In conclusion, our findings suggest that post-ischemic administration of AG exhibits a neuroprotective effect against ischemia–reperfusion injury of sciatic nerve. However, further investigations are required to delineate the detailed mechanisms underlying the protective effect of AG in sciatic nerve injury.

I Jafari Anarkooli, H Barzegar Ganji,
Volume 20, Issue 83 (8-2012)

Axillary artery, the continuation of the Subclavian artery, initiates at the lateral border of the first rib and normally ends at the lower border of teres major, where it obtains the name of brachial artery. Variations in the branching pattern of the axillary artery are common. During a routine dissection of a 25-30-year-old man cadaver, based on the classic Grant’s method, in the Department of Anatomy at Zanjan University of Medical Sciences, we observed an unusual branching in the second part of the left axillary artery. In spite of the existence of thoracoacromial trunk, the second part of the axillary artery had a common trunk for lateral thoracic and thoracodorsal arteries. The thoracodorsal artery accompanying the thoracodorsal vein and nerve entered lattissimus dorsi muscle. The axillary artery has the highest rate of rupture and damage after the popliteal artery, and it can get damaged in an attempt to either reduce old shoulder dislocations or remove axillary lymph nodes. Therefore, a full awareness of the axillary artery variations could prove very useful and essential for medical specialists, especially vascular surgeons, orthopedic surgeons, radiologists, and anatomists.

A Abdanipour, R Nejatbakhsh, I Jafari Anarkooli, M Ghorbanli, A Nikfar, A Noriyan,
Volume 24, Issue 105 (6-2016)

Background and Objective: Nowadays, extensive research is carried out on the effect of plant extracts on variety of disorders. In this study, the effect of hydroethanolic extract of Lavandula officinalis on proliferation of neural stem cells as well as its anti-apoptotic properties was assessed.

Materials and Methods: Neural stem cells were isolated from hippocampus of neonatal rat brain. To determine the optimal concentration of Lavandula officinalis extract, isolated neural stem cells were treated with 200, 400, 600, 800 and 1000 µg/ml of concentrate for 48 h. Then cell proliferation rate was evaluated via MTT assay. Meanwhile, the anti-apoptotic property of Lavandula officinalis extract was evaluated using TUNEL assay method. 

Results: The results of this study showed a significant difference in cell proliferative and anti-apoptotic property of Lavandula officinalis extract on neural stem cells comparing to the control group.

Conclusion: The hydroethanolic extract of Lavandula officinalis can be effective on proliferation elevation  and apoptosis reduction  in rat neural stem cells.

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