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Showing 9 results for Khosravi

F Gharibdoost, M Karimifar, M Akbarian, Ap Meisami, F Shahram, F Davachi, Ar Jamshidi, M Akhlaghi, Ah Naji, Sh Khosravi,
Volume 14, Issue 54 (Mar 2006)

Background & Objective: Systemic lupus erythematosus (SLE) is a disease with life-threatening complications. Since evidence indicates that measurement of triglyceride (TG) and HDL levels and tumor necrosis α factor (TNF- α) and its types I and II soluble receptors plays a major role in evaluation of lupus activity, this study was conducted to investigate the relationship between the above mentioned factors and lupus activity in Tehran in 2005. Materials & Methods: In this cross-sectional study fasting blood samples were obtained from 86 SLE patients who had been entered into the study through convenient sampling and the disease activity was calculated using the Systemic Lupus Erythematosus Disease Activity Index [SLEDAI]. Scores ≥ 6 were considered as active lupus and <6 as dormant lupus. Serum levels of TNF- α, sTNFR1 and sTNFR2 were measured through ELISA (Bender Medsystem) and blood TG and HDL through routine biochemical tests within 12 hours overnight fasting. The results were analysed by t-test, Mann-Whitney and Pearson correlation tests. Results: 46 people (53.5%) suffered from dormant disease and 40 people (46.5%) from active disease. TG level had significant relationship with disease activity, sTNFR2 (P=0.001) and TNF-α (P=0/01), while HDL level had inverse significant relationship with SLEDAI (P=0.007), TNF (P=0.01), STNFR1 (P=0.001). There was no significant relation between TG and HDL with STNFR2. Multiple linear analysis of regression showed that three variables (TG, sTNFR1 and sTNFR2) are maintained in the model for prognosis of the disease while TNF-α and HDL are omitted. Conclusion: Dislipoproteinemia (elevated TG and reduced HDL) correlates with SLE activity following an increase in TNF-α and its soluble receptors. Thus, serum levels of TG, HDL and TNF-α and its soluble receptors are connected with lupus activity and are valuable markers for the disease activity.

H Khosravi, M Amini, S Haghighi, D Ghodsi, A Kosravi, M Kalateh Jari,
Volume 14, Issue 57 (Dec 2006)

Neuroleptic Malignant Syndrome (NMS) is a rare but potentially fatal problem induced by the consumption of antipsychotic drugs, especially traditional drugs which are more common in youngsters and males. This paper describes the first reported case of a clinical presentation of NMS (induced by the consumption of Risperidone) in an old woman, who was suffering from psychotic processes. Due to psychotic depression and with differential diagnosis of schizoaffective, the woman had been prescribed a low and medium dosage of Risperidone, but she suddenly and unexpectedly developed clinical NMS. Despite special treatments and services, she passed away after 14 days. In spite of rare universal reports regarding the development of NMS induced by the consumption of Risperidone, so far no occurrence of NMS in aged women has been reported.

E Asdollahy, A Khosravi, P Oneil,
Volume 18, Issue 70 (3-2010)

Background and Objective: Resistance to chloroquine (CQ) in Plasmodium falciparum malaria has become a major health concern in the developing countries. This problem has prompted investigators for finding alternative antimalarials that may be effective against resistant strains. Amodiaquine (AQ) is an antimalarial which is effective against many chloroquine-resistant strains of P. falciparum. However, clinical use of AQ has severely been restricted because of its hepatotoxicity and agranulocytosis side effects. The aim of this study was to design and examine the effects of new analogues of amodiaquine. Materials and Methods: A successful four-step synthesis of a new series of 4-fluoro analogues was designed and applied to the synthesis of an array of 10 analogues. Antimalarial activity of these agents was assessed against chloroquine-resistant (TM6) and sensitive strains (3D7) of P. falciparum. Results: Several analogues have shown potent antimalarial activity against sensitive 3D7 strain of the parasite. The 6h analogue was superior to the pyrollidino analogue 6b against all of the strains examined. The N-tert butyl analogue 6b was potent against chloroquine resistant strains, though it was not quite as active as amodiaquine (AQ) against both chloroquine sensitive and resistant parasites. Conclusion: From the different analogues made, it was shown that the analogue 6h was more potent than the others. However, this analogue has equal or slightly less potent than amodiaquine and chloroquine against P. falciparum. Further studies on the metabolism and pharmacokinetics of 6h are recommended.

P Yazdanpanah, Sh Amirhasani, A Mousavizadeh, P Ghaffari, Z Khosravi, A Khademi,
Volume 20, Issue 79 (5-2012)

Background and Objective: Carpal tunnel syndrome (CTS) is caused by the entrapment of the median nerve in the carpal tunnel of the wrist. CTS is a rather frequent complication in pregnancy. Thud, the prevalence of CTS is higher in women compared to men. However, the percentage of CTS related to pregnancy is not known in some countries such as Iran. The main aim of this study was to determine the prevalence and severity of CTS in pregnant and non-pregnant women of Boyerahmad township. Materials and Methods: This is a cross-sectional descriptive study was done during the period of February 2010 to January 2011 in OB&GYN clinics among 2,656 non-pregnant and 1,508 pregnant women. Among the women whom were referred to the OB&GYN specialists, 175 exhibited the clinical symptoms of CTS and were subjected to standard electrodiagnostic studies performed for either ruling in or out CTS by a Physiatrist. Results: The prevalence of CTS in women who had clinical symptoms was 2.7%. The prevalence of CTS in pregnant and non-pregnant women was 3.4% and 2 .3%, respectively. Overall, out of a total of 51 pregnant women who were suffering from CTS, 59.4% had mild, 18.8% had moderate, and 21.9% had severe CTS. Sixty one non-pregnant women had CTS that 73.6% of whom had mild, 20.8% had moderate, and 5.6% had severe CTS. Conclusion: The prevalence of CTS in pregnant women is higher than non-pregnant women. Also the rate of severe CTS is higher among pregnant women.

S Yosaee, As Gharamaleki, A Zamani, A Khosravi, K Jafarian,
Volume 21, Issue 88 (7-2013)

Background and Objective: Sleep Diary is the most practical and cost-effective tool for evaluating sleep habits. However, measurement errors are common issues with self report methods in medical research. The aim of the present study was to evaluate a self- report method compared to Actigraph in assessing sleep patterns in children. Materials and Methods: This cross-sectional study was conducted on 270 children aged 6 to 9 years who were selected by multistage sampling in primary schools of Tehran. The sleep patterns during a week were measured using two methods of self- report and Actigraph. The parents were asked to report the sleep pattern of their children. Results: The results of the current study indicated that sleep duration determined through the self- report method was overestimated compared to Actigraph (P=0.001). Parents reported the onset of children sleep significantly earlier than Actigraph (P=0.001). There was no significant difference between self- report and Actigraph for wake -up time. Conclusion: The findings of this study illustrate low accuracy of self- report method for determining sleep duration and sleep onset in children. Although, self report is a valid method for measuring wake -up time in children, it has a low validity for assessing the other components of sleep pattern.
T Elahi, R Khosravi, S Rashidi Rashtabadi, A Akhavan,
Volume 22, Issue 92 (5-2014)

Background and Objective: Staying away from the familiar surroundings and family supports, along with weaknesses in capabilities, skills and aging- related failures can lead to mental problems in the elderly residing in nursing homes. Therefore, it is necessary to identify and strengthen the factors that reduce the old people’s vulnerability to these problems. One of the factors neglected in this area is hope. Hence, the aim of the present study was to examine the role of hope in mental problems of the elderly residing in nursing homes. Materials and Methods: In this descriptive- correlational study, 60 elderly (28 females and 32 males) with normal IQ, without severe physical and cognitive problems from the nursing homes of Zanjan city were selected by using full census method. The data was collected using demographic researcher-made questionnaire, Snyder hopefulness and SCL-90-R measures. Results: Data analysis using Pearson correlation coefficient and multivariate linear regression indicated significant relationship in general, operative and strategic hope and GSI and some of its dimensions. Operative, strategic and general hope exhibited significant and relatively high variance in GSI and dimensions of depression, somatization, anxiety, hostility and paranoid (7, 7, 14, 9, 21 and 17.5%, respectively). Beta coefficients showed that higher scores in predictive variables led to lower mental problems and better mental health in the elderly. Conclusion: Hopefulness toward the future through strengthening forbearance of the existing circumstances, is regarded as a key element in facing stressful situations and reduces the elderlys’ vulnerability to mental disorders.

M Azhdari, Bbf Haghiroalsadat, H Mozaffari-Khosravi, M Jalilimanesh,
Volume 22, Issue 95 (8-2014)

Background and Objective: Burn injury is not a disease, but it is a disaster with many social, economic and mental effects which contribute to the problem and make it several times larger. Several studies have examined various factors in burn. In this study, we evaluated the effect of L-glutamine on biochemical tests in mice with second degree burns. Materials and Methods: In this experimental study, 30 male mice were included and randomly divided into two groups. First, the mice underwent general anesthesia and then using an iron plate with 80°C thermal injury for duration of one second, a second-degree burn injury was induced on the animal's skin. In the case group, the mice received glutamine powder (1 g/kg/day) dissolved in water. The control group did not receive such supplementation. The data gathered on different days and analyzed by SPSS software. Results: There was no significant difference between two groups regarding weight and serum albumin, urea, and creatinine levels. The mean of serum levels of albumin is (4.93±0.24 and 4.84±0.79) on day 1 and 22th respectively (P≤0.4) and in the control group on day 1 and 22th (4.21 ± 0.46 and 4.21 ± 0.45) respectively (P≤0.7). The mean of serum levels of urea is (30.10 ± 3.3 and 30.48 ± 4.27) on day 1 and 22th respectively (P≤0.3) and in the control group on day 1 and 22th (25.89 ± 0.14 and 25.89 ± 2.4) respectively (P≤0.7). The mean of serum levels of creatinine is (0.82 ± 0.17 and 0.86 ± 0.25 on day 1 and 22th respectively (P≤0.9) and in the control group on day 1 and 22th (0.86 ± 0.14 and 0.86 ± 0.19) respectively (P≤0.4). Conclusion: The results of this study indicate that glutamine did not have any significant effect on biochemical parameters in burn. The role of glutamine in burn wound healing has not been established completely, but there is a lot of evidence supporting the beneficial effects of glutamine for treating burns. However, further research is necessary in order to understand which stage of the treating process glutamine supplementation affected. References 1- Ansari H. Burn, Iran Uni Med Sci. Tehran: 2003. 2- Brunicardi FC, Andersen DK, Billiar TR, et al. Schwartz’s Principles of Surgery. 9th ed. New York, NY: McGraw-Hill Medical 2010. 3- Tang YW. The effect of burn plasma on skeletal muscle proteolysis in rats. Burns. 2003 29(2): 107-13. 4- Lu X, Han CM, Yu JX, Fu SZ. Preliminary comparative study on the effects of early enteral supplementation of synbiotics on severely burned patients. Zhonghua Shao Shang Za Zhi. 2004 20(4): 198-201. [Chinese]. 5- Azar A, Moemeni M, Statistics and its application in management. Samt Tehran: 2006. 6- Wernerman J. Clinical use of glutamine supplementation. J Nutr. 2008 138(10): 2040S-2044S. 7- Chai JK, Sheng ZY. A brief account of prevention and treatment of infection in burn patients. Zhonghua Shao Shang Za Zhi. 2008 24(2): 84-86. [Chinese]. 8- Gismondo MR, Drago L, Fassina MC, Vaghi I, Abbiati R, Grossi E. Immunostimulating effect of oral glutamine. DigDis Sci. 1998 43(8): 1752-4. 9- Van den Heuvel RH, Curti B, Vanoni MA, Mattevi A. Glutamate synthase: a fascinating pathway from L-glutamine to L-glutamate. Cell Mol Life Sci. 2004 61(6): 669-81. 10- Guo GH, Deng ZY, Wang YX, Xing JJ, Peng Y, Li GH. Effects of glutamine enriched enteral feeding on immunoregulation in burn patients. Zhonghua Shao Shang Za Zhi. 2007 23(6): 406-408. [Chinese]. 11- Cleon WG, Finkelstein L, Michael RM. Burns. Schwartz’s Principles of Surgery. 7th ed. New York, NY: McGraw- Hill 1999. 12- Yan H, Zhang Y, Lv SJ, Wang L, Liang GP, Wan QX, Peng X. Effects of glutamine treatment on myocardial damage and cardiac function in rats after severeburn injury. Int J Clin Exp Pathol. 2012 5(7): 651-9. 13- Peng X, Yan H, You Z, Wang P, Wang S. Glutamine granulesupplemented enteral nutrition maintains immunological function in severely burned patients. Burns. 2006 32(5): 589-93. 14- Watford M. Glutamine metabolism and function in relation to proline synthesis and the safety of glutamine and proline supplementation. J Nutr. 2008 138(10): 2003S-7S. 15- Mahan l, Raymond J, Escott-Stump S, Krauses food, nutrition & diet therapy, 12th ed, California, United states. 2008. 16- Berger MM, Binnert C, Chiolero RL, et al. Trace element supplementation after major burns increases burned skin trace element concentrations and modulates local protein metabolism but not whole-body substrate metabolism. Am J Clin Nutr. 2007 85(5): 1301-6. 17- Suckow M, Dannem P, Brayton C. The Laboratory Mouse.2th ed. Boca Raton: United State 2006 18- Fan J, Meng Q, Guo G, et al. Effects of enteral nutrition supplemented with glutamine on intestinal mucosal immunity in burned mice. Nutrition. 2009 25(2): 233-9. 19- Peng X, Yan H, You Z, Wang P, Wang S. Effects of enteral supplementation with glutamine granules on intestinal mucosal barrier function in severe burned patients. Burns. 2004 30(2): 135-9. 20- Hasebe M, Suzuki H, Mori E, Furukawa J, Kobayashi K, Ueda Y. Glutamate in enteral nutrition: Can glutamate replace glutamine in supplementation to enteral nutrition in burned rats? J Parenter Enteral Nutr. 1999 23(5 Suppl): S78-S82. 21- Shahabi S, Hashemi S, Shahrokhi S, et al. Hypertermia can accelerate the healing process of 2 degree burn wounds. J Kerman Univ Med Sci. 2005 3(4): 110-8. 22- Karimipour M, Zarei L, Ilkhani Zadeh B, Rajaei F, Shirpour A. The effects of nitric oxide on wound healing in burned rats. J Iranian Anatomic Sci. 2006 3(4): 253-9. 23- Salman B, Oguz M, Akmansu M, et al. Effect of timing of glutamine-enriched enteral nutrition on intestinal damage caused by irradiation. Adv Ther. 2007 24(3): 648-61. 24- Chen Z, Wang S, Yu B, Li A. A comparison study between early enteral nutrition and parenteral nutrition in severe burn patients. Burns. 2007 33(6): 708-12. 25- Wang SL. Progress of burn research in metabolism and nutrition in China. Zhonghua Shao Shang Za Zhi. 2008 24(5): 396-9. [Chinese]. 26- Tavakoli R, Nabipour F, Najafipour H, Hadian M, Aliyaee G, Talebian S. Comparison of the effect of infrared (IR) and Phenytoin cream on skin wound healing in rat. J Babol Univ Med Sci. 2004 6(2): 7-11. 27- Tavakoli R, Nabipour F, Najafipour H. Effect of betadine on wound healing in rat. J Babol Univ Med Sci. 2006 8(3): 7-12. 28- Planche T, Dzeing A, Emmerson AC, et al. Plasma glutamine and glutamate concentrations in Gabonese children with Plasmodium falciparum infection. QJM. 2002 95(2): 89-97. 29- Aguayo-Becerra O, Torres-Garibay C, Macías-Amezcua MD, et al. Serum albumin level as a risk factor for mortality in burn patients. Clinics (Sao Paulo). 2013 68(7): 940-5. 30- Pérez-Guisado J, de Haro-Padilla JM, Rioja LF, Derosier LC, de la Torre JI. Serum albumin levels in burn people are associated to the total body surface burned and the length of hospital stay but not to the initiation of the oral/enteral nutrition. Int J Burns Trauma. 2013 3(3): 159-63. 31- Jeschke MG, Debroy MA, Wolf SE, Rajaraman S, Thompson JC. Burn and starvation increase programmed cell death in small bowel epithelial cells. Dig Dis Sci. 2000 45(2): 415-20.

R Rezaei, A Almasi-Hashiani , A Rashidi , Sm Vaez, A Khosravi ,
Volume 24, Issue 103 (4-2016)

Background and Objective: Macular edema is an important cause of visual loss in diabetic patients which can lead to permanent vision loss in untreated cases. This study compares the efficacy of intravitreal injection and the sub-tenon capsule of triamcinolone on the visual acuity in patients with diabetic retinopathy.

Materials and methods: In this randomized clinical trial study, 82 diabetic retinopathy eyes were randomly assigned to intravitreal triamcinolone injection group and 74 eyes to sub tenon capsule injection. In terms of visual acuity and intraocular pressure, patients were followed up after first week, first month, and 3rd month. The collected data were analyzed using ANOVA with repeated data (Repeated ANOVA) and  Stata software (version 13).

Results: Crude comparison between groups  did not exhibit significant differences. However, by controlling the confounding baseline effect, level of visual acuity, logMar[d1]  of the visual acuity in the  intravitreal injection group (-0.78) was significantly less than the sub-tenon capsule group (-0.67). Also, after controlling for other confounding variables (age and sex), the mean IOP was significantly higher in the intravitreal injection group.

Conclusion: [d2] Visual acuity in intravitreal injection group was significantly less than the sub-tenon capsule group and also the mean IOP was higher in the intravitreal injection group. Therefore, sub-tenon capsule of triamcinolone stands out as a superior approach.

Ranaee Ranaee , Maryam Khosravi, Zeinab Vosough,
Volume 27, Issue 121 (March-April 2019)

Eosinophilic cholecystitis is a rare inflammatory condition encountered in surgical cholecystectomy specimens. In terms of histopathology, it is defined by transmural infiltration of eosinophils composing more than 90% of leukocytes. We here report a case of 19-year-old male admitted with thalassemia intermedia and with severe left upper quadrant pain. The patient underwent open splenectomy and cholecystectomy. In his histopathologic examination eosinophilic infiltration was found in gallbladder wall.

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