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Mr Palizvan, A Esmaeili, H Rajabian, Y Jand, E Mirzazadeh,
Volume 14, Issue 56 (Sep 2006)

Background & Objective: Regarding the high prevalence of epileptic seizures, its complications and the necessity to control them, this study was carried out in order to assess the role of progesterone administration in newborn rats on Pentylenetetrazol (PTZ) kindling susceptibility after maturity. Materials & Methods: This experimental study was carried out on 32 newborn Wistar rats. Rats were randomly divided into four groups, which are as follows: progesterone-injected females, progesterone-injected males, sesamoid-injected females and sesamoid-injected males. Progesterone and sesamoid groups were injected with progesterone (100 mg/Kg) and sesamoid (100 mg/Kg) respectively. Sixty days after injection chemical kindling in the rats was analyzed by PTZ administration. Results: Progesterone significantly increased the susceptibility for PTZ kindling in female rats however it did not have a significant effect on seizure parameters in male rats. Conclusion: The results of this study suggest that chronic administration of progesterone can only increase susceptibility for chemical kindling in female rats and not in the males.

P Zareie, M Sadegh, Mr Palizvan,
Volume 25, Issue 109 (4-2017)

Background and Objective: In spite of various and effective anti seizure drugs available, 30% of epileptic patients are not adequately treated with current medications. Based on the effectiveness of phytocannabinoids on epileptic and seizure models, in this study the effects of 2-achidonoylglycerol (2-AG) injection, as an important endocannabinoid, on tonic-clonic seizures induced by pentylenetetrazol (PTZ) was examined.  

Materials and Methods: The study was performed on male wistar rats (180-200 g). Tonic-clonic seizures were induced through a single intra-peritoneal injection of PTZ (80 mg/Kg) and then seizure behavior was monitored for 30 minutes. The intra-peritoneal injection of 2-AG (1 mg/Kg) in dimethyl solfoxide (DMSO) was performed 15 minutes before the PTZ injection. In the sham group an equivalent volume of DMSO was injected 15 minutes before PTZ. Data on the delay of seizure stage occurrence, duration of the stages, number of occurrences for each stage and mortality rate due to tonic-clonic seizures were collected for analysis.

Results: PTZ injection in association with DMSO significantly increased the delay for seizure stages 1 and 2, in comparison with just a PTZ injection (P<0.05), but had no significant effect on the duration and delay of seizure stages 3-5. Intra-peritoneal injection of 2-AG in association with DMSO before the injection of PTZ had no significant effect on the delay and duration of seizures but reduced the occurrence of each seizure stage and also reduced mortality due to tonic-clonic seizures in comparison with PTZ injection associated with DMSO. The mean seizure stage was also significantly decreased (P<0.05).

Conclusion: It seems 2-AG injection could be effective in reducing seizure parameters in seizures induced by PTZ.

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