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Showing 3 results for Rezaee

Z Ghahremani, S Rezaee- Kalaj, Mr Zarrindast, B Jahanguiri, Mr Jafari,
Volume 17, Issue 67 (8-2009)

Background and Objective: JWH133 is known to have cannabinoid-2 (CB2) receptor agonist properties. Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is also known to have antinociceptive properties. Endocannabinoids produce analgesia possibly through cyclooxygenase (COX) pathway. The aim of the present work was: to study the effect of celecoxib on JWH133 induced antinociception and to compare the effects of two different dose ranges of celecoxib (mg/kg and nano g/kg) on the JWH133 antiniciceptive effect. Materials and Methods: We have studied the possible interaction of administration of mg/kg (50-200 mg/kg) and Ultra-Low Dose (ULD) (25 and 50 ng/kg) of celecoxib on the antinociceptive effect of intraperitoneal (i.p.) injection of JWH133 using formalin test in mice. Results: JWH133 (0.01, 0.1 and 1 mg/kg) induced antinociceptive effect just in phase I of the formalin test. Celecoxib (50-200 mg/kg) and its ULD (25 and 50 ng/kg) attenuated and potentiated, JWH133 induced antinociception, respectively. Conclusions: It is concluded that JWH-133 induced antinociception is modulated by celecoxib and mg/kg doses of celecoxib showed opposite effects compare to its ultra-low doses.

E Darabi, H Asilian, R Gholamnia, A Rezaee, A Jonidi Jafari, A Khavanin,
Volume 17, Issue 68 (9-2009)

Background and Objective: Polychlorinated biphenyls (PCBs) are toxic, persistent, bio-accumulate and pose a risk of causing adverse effects on human health and to the environment. PCB compounds exert varios impacts on human depending upon age, route of entry, intensity and frequency of exposure. This study was conducted to determine the effect of UV-C, hydrogen peroxide and solvent on the photodegradation of PCBs. Materials and Methods: The photochemical reactor was of annular geometry (500 ml volume) with a cylindrical low-pressure mercury lamp emitting at 254 nm. The power emitted by the lamp was 6 W. The whole lamp was immersed into a reactor with temperature of 32 ± 2 C. The PCBs were analyzed by GC/ECD equipment. Results: The degradation of total PCBs in terms of one, two and three lamps was 77.5%, 82.9% and 85.2% respectively. The degradation of total PCBs in terms of not using of H2O2 and using 10% and 20% of H2O2 were 74.5%, 79% and 94.5% respectively. Conclusion: The results of this experiments showed that UVC-photolysis of H2O2 leads to a degradation efficiency of PCBs only in the presence of ethanol.

F Movahed, F Lalooha, R Moinodin, T Dabbaghi Ghale, Z Rezaee Majd, Z Yazdi,
Volume 25, Issue 108 (3-2017)

Background and Objective: In the past three decades, the efficacy of using low dose aspirin for preeclampsia prevention has been an important matter in obstetrics research. The purpose of this study was to determine the effectiveness of aspirin in the prevention of preeclampsia in high risk women with abnormal uterine artery Doppler ultrasonography findings.

Materials and Methods: This randomized double blind clinical trial was done in Kowsar hospital in Qazvin, Iran in 2015. All singleton pregnant women at 11-14 weeks of gestation were evaluated by uterine artery Doppler ultrasound and in the case of abnormal findings, were divided into two groups of case (n=50) and control (n=50). The case group received aspirin 80 mg/day and the control group received daily placebos. Both groups were followed up until delivery and pregnancy outcomes including incidence of preeclampsia, intrauterine growth restriction, preterm labor, mode of delivery, 1st and 5th min Apgar score and neonatal birth weight were recorded. All these data were analyzed with T-Test and Chi-square statistical methods.

Results: Preeclampsia occurred in 6 individuals (12%) in the case group and 12 individuals (24%) in the control group, however this reduction was not statistically significant (P=0.3). No significant difference was observed between the two groups in fetal growth restriction, preterm labor, mode of delivery and Apgar score. Average birth weight in the case group was slightly higher than the control group (P=0.05).

Conclusion: The findings of this study demonstrated that the administration of aspirin from 14 weeks of gestation to women with abnormal Doppler ultrasonography findings could not reduce the risk of preeclampsia.

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