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Showing 2 results for Sarmadian

F Didgar, H Sarmadian, N Zarin Far, M Rafiee, M Choghae,
Volume 20, Issue 80 (7-2012)

Background and Objective: Brucellosis is an endemic disease in Iran that has a worldwide spread and is associated with chronic disabilities in humans. Combination therapy of brucellosis leads to recovery of symptoms, shortening of the symptomatic intervals, and decrease in the rate of relapse and drug resistance. Considering the use of rifampin in the treatment of tuberculosis, and the necessity for an alternative treatment in regions endemic for both tuberculosis and brucellosis, in this study we compared the efficiency of the WHO's standard regimen of rifampin-doxycycline (RD) versus ciprofloxacin-doxycycline (CD) for the treatment of brucellosis. Materials and Methods: This randomized controlled trial was performed on 90 patients, affected with brucellosis, who were referred to the Infectious Disease Clinics at Arak University of medical sciences. The patients were randomly divided into two groups: the DR group, received 100 mg of Doxycycline twice a day and 300 mg of rifampin Bid daily for eight weeks and the CD group, received 100 mg of doxycycline plus 500 mg of ciprofloxacin twice a day for eight weeks. The patients were analyzed for the relief of symptoms, drug side effects, and laboratory findings during the treatment. Results: In this study, the rate of symptom relief and laboratory findings in both groups were similar. The relief of symptoms was seen in 93.2% and 83.9% of the patients for the DR and CD groups, respectively (P=0.182). The side effects of the drug were not significant in either groups, with no significant difference, and did not lead to discontinuation of the therapy. Conclusion: Due to the similar efficacy of CD and DR regimens in the treatment of brucellosis and considering the usage of rifampin in regions with high prevalence of tuberclusis, the CD regimen is recommended as an appropriate treatment.

M Sofian, F Zolfaghari, H Sarmadian, A Ramezani, Aa Farazi,
Volume 20, Issue 82 (7-2012)

Background and Objective: Brucellosis is an enzootic disease that can involve many organs and tissues. Brucella epididymo-orchitis is a focal complication of the brucellosis. The aim of this study was to compare epidemiologic, clinical, and laboratory features of patients suffering from Brucella induced epididymo-orchitis with cases of nonspecific epididymo-orchitis. Materials and Methods: This analytical cross-sectional study was performed in Valiasr Hospital in Arak from 2007 to 2011. A total of 40 cases of Brucella epididymo-orchitis were compared with 40 cases of bacterial (non-specific) epididymo-orchitis and the data were analyzed by SPSS ver.16 software and Student t-test, and Mann-Whitney U and chi-square tests. Results: We found no significant differences between the age (P-value = 0.82), fever (P-value = 0.17), history of urologic manipulation (P-value= 0.23), increased ESR (P-value = 0.28), and positive CRP (P-value = 0.45) between the two groups. However, there was a significant difference between the presence of arthritis and arthralgias (P-value = 0.02), leukocytosis (P-value <0.05), pyuria (P-value = 0.002), symptoms of dysury-frequency (P-value = 0.004), sweating (P-value <0.05), and location (P-value =0.004) between the two groups. Conclusion: This study shows that the existence of epididymo-orchitis without symptoms like dysuria and frequency, leukocytosis, and pyuria is suggestive of brucella epididymoorchitis. The physicians in endemic areas could use these findings for expediting the diagnosis and treatment of Brucella epididymo-orchitis.

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