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Showing 6 results for Vaez

S Nabavi, Mh Behzad Moghadam, Mh Arab Hosseini, M Vaezi, R Rajabi,
Volume 19, Issue 75 (4-2011)

Background and Objective: Hyperbilirubinemia is a common neonatal abnormality. Severe hyperbilirubinemia is a risk factor for auditory system injury. Auditory brainstem responses (ABR) are important in early diagnosis of hearing impairments in healthy term infants with elevated bilirubin levels requiring exchange transfusion. Materials and Methods: During a two- year- period (2007 – 2009), in a prospective descriptive analytical study, in Tehran Milad Hospital, 64 (32 female, 32 male), healthy term (> 37 weeks) infants, who required treatment or were treated with phototherapy or received exchange transfusion for elevated bilirubin levels or jaundice, were studied. After obtaining a written consent from their parents, the infants were tested with auditory brain responses and results were analyzed using SPSS 16 software. Results: No significant correlation was found between ABR and age, weight, bilirubin level or ABO blood group. Nineteen out of 64 infants received exchange transfusion. Three out of 19 infants (16%) exhibited abnormal ABR and 16 infants (84%) had normal ABR. There was no significant correlation between exchange transfusions and ABR (P>0.05). Conclusion: The results pointed out that 14% of the infants with elevated bilirubin who required exchange transfusion had abnormal ABR. This indicates that elevated bilirubin levels even without inducing kernicterus should be considered as risk factors for hearing impairments. Further studies are needed on how long these tests may remain abnormal.

Bm Torabi, A Shiravi, Gh Vaezi,
Volume 20, Issue 82 (7-2012)

Background and Objective: One of the most important complications of utilization of anti-epilepsy drugs in pregnancy is an increase of fetal abnormality. There is not enough information about the role of phenytoin on teratogenic effects on pregnancy and on fetal organogenesis. Hence, this study was designed to determine the macroscopic abnormalities created by continuous use of phenytoin during organogenesis of fetus. Materials and Methods: Forty pregnant mice (NMRI type) were divided into three experimental groups (I, II, III) and one control group. Three experimental groups I, II, III received 60mg/kg, 75 mg/kg, and 90 mg/kg per day with 0.2 ml volume from the day 6.5 (GD6/5) to day 14.5 (GD‌14/5) of pregnancy intraperitoneally (i.p.). The control group received the same volume of normal saline instead. The mice on the day 18.5 of pregnancy were sacrificed, and their tail lengths, weights, and abnormalities were studied. Data were analyzed by ANOVA and Tukey tests. Results: In the experimental groups, the mean weight and tail length was reduced significantly compared to the control group (P<0.05). In all three experimental group (I, II, III) abnormalities such as absorption of same fetal, hemorrhage in different organs and follicular thyroid was increased significantly compared to the control group (P<0.05). Conclusion: Our results show that utilization of the drug phenytoin in mouse during organogenesis not only induces absorption of some fetuses, weight loss, and tail length reduction, but it can also induce abnormalities such as hemorrhage and follicular thyroid.

D Shackebaei, M Vaezi, M Hesari, A Asadmobini,
Volume 21, Issue 88 (7-2013)

Background and Objective: Hypothyroidism decreases cardiac contractility and heart rate. Since cardiac function is also modulated by diazepam, the aim of this study was to investigate the direct effect of diazepam on the isolated hypothyroid rat heart. Materials and Methods: This experimental study was conducted on 30 rats in four groups (control, hypothyroid, control diazepam and hypotyroid+diazepam). According to Langendorff method, isolated hearts were retrogradly perfused with Krebs solution and passed 3 stages of baseline, ischemia and reperfusion. Cardiac parameters including left ventricular developed pressure, Heart Rate (HR) and Rate Pressure Product (RPP) were calculated. Results: At baseline, heart function significantly decreased in hypothyroid group compared with control and control diazepam groups (P=0.01 & P=0.001 respectively). Percentage decline of HR and RPP at baseline stage after diazepam administration, was significantly different in the control diazepam and hypothyroid+diazepam groups (P=0.001 & P=0.002 respectively). Recovery percentage of RPP in reperfusion stage significantly increased in hypothyroid group (% 60±5) compared with control (% 38±5) and in hypotyroid+diazepam group (% 87±8) compared with hypothyroid group (%60±5), (P<0.0001 & P=0.02, respectively). Conclusion: Administration of diazepam exacerbates the effect of hypothyroidism at baseline and reperfusion stages in rats. In other words, diazepam perfusion leads to greater decline of hypothyroid rat heart function at baseline and higher recovery percentage at the reperfusion stage. These effects can be due to the common effects of hypothyroidism and diazepam on the L-type calcium channels or the amount of oxygen consumption in rats.
H Kalalian Moghaddam, Gh Vaezi, M Mesripour Alavijeg, M Salimi, F Ghanbari,
Volume 22, Issue 95 (8-2014)

Background and Objective: Increasing evidence has shown that diabetes induces cognitive dysfunction and impairs learning and memory. Berberine is an isoquinoline alkaloid and vitamin E is a fat-soluble antioxidant with multiple pharmacological effects on diabetes. Thus, we investigated the effect of Berberine hydrochloride and vitamin E on diabetes-induced cognitive dysfunction in rats. Materials and Methods: 48 male Wistar rats were randomly selected and allocated in 6 control groups: control treated with vitamin E (30mg/kg), diabetic and Berberine-treated diabetic group (100mg/kg), vitamin E-treated diabetic group (30mg/kg) and a diabetic group treated with both vitamin E and Berbrine. Diabetes was induced by STZ administration at dose of 55mg/kg through Intraperitoneal injection route. Berberine hydrochloride and vitamin E were administered per os, respectively at doses of 100 and 30 mg/kg/day 1 week after STZ injection for a period of 6 weeks. Blood samples were taken from the tail vein 1, 3, 5, 7 weeks after STZ injection to measure blood glucose levels. Behavioral tests including spatial recognition and objective recognition were performed at the end of the study. Results: Diabetic group treated with both drugs demonstrated significant behavioral differences as compared to diabetic, vitamin E-treated diabetic (30mg/kg), and Berberine -treated diabetic (100mg/kg) groups. In the meantime, cognitive test value demonstrated an increase in this group. Conclusion: Berberine hydrochloride and vitamin E administration for 6 weeks improve cognitive dysfunction in streptozotocin -induced diabetes in rats. References 1- Pop-Busui1 R, Sima A, Stevens M, Diabetic neuropathy and oxidative stress. Diabetes Metab Res Rev. 2006 22: 257-273. 2- Galer BS, Gianas A, Jensen MP. Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life. Diabetes Res Clin Pract. 2000 47: 123-28. 3- Yoshikawa T, Yasuda M, Ueda S, et al. Vitamin E in gastric mucosal injury induced by ischemia- reperfusion. Am J Clin Nutr. 1991 53: 2105-45. 4- Devaraj S Jialal I. Alpha-tocopherol decreases tumor necrosis factor-alpha mRNA and protein from activated human monocytes by inhibition of 5-lipoxygenase. Free Radic Biol Med. 2005 38: 1212-1220. 5- Parihar MS, Chaudhary M, Shetty R, Hemnani T. Susceptibility of hippocampus and cerebral cortex to oxidative damage in sterptozotocin treated mice prevention by extracts of Withania somnifera and Aloe vera. J Clin Neurosci. 2004 11: 397- 402. 6- Scarano WR, Messias AG, Oliva SU, Klinefelter GR, Kempinas WG: Sexual behavior, sperm quantity and quality after short-term sterptozotocin-induced hyperglycaemia in rats. Int J Androl. 2006 29: 482-488. 7- Vuddanda PR, Chakrabory S, Singh S. Berberine: a potential phytochemical with multispectrum therapeutic activities. Drugs. 2010 10: 1297- 1307. 8- Kong WJ, Zhang H, Song DQ, et al. Berberine reduce insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression. Metabolism. 2009 58: 109-19. 9- Zou J, Zhou S, Tang J, zhang K, Guang L, Huang Y, et al. Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/ high-fat diet-induced diabetic rats. Eur J Pharmacol. 2009 606: 262-268. 10- Sharma B, Salunke R, Balomajumder C, Daniel S, Roy P. Anti-diabetic potential of alkaloid rich fraction from. Capparis decidua on diabetic mice. J Ethnopharmacol. 2010 127: 457-462. 11- Hua-Dong Wang, Da-Xiang Lu, Ren-Bin Qi, Therapeutic strategies targeting the LPS signaling and cytokines. Pathophysiol. 2009 16: 291-296. 12- Tsoureli Nikita E, Hercogova J, Lotti T, Menchini G. Evaluation of dietary intake of vitamin E in the treatment of atopic dermatitis: a study of the clinical course and evaluation of the immunoglobulin E serum levels. Int J Dermatol. 2002 41(3): 146-50. 13- Sena CM, Nunes E, Gomes A, Santos MS, Proenca T, Martins MI, Seica RM. Supplementation of coenzyme Q10 and alpha-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats. Nutr Res. 2008 28: 113-121. 14- Al Shamsi M, Amin A, Adeghate E. Beneficial effect of vitamin E on the metabolic parameters of diabetic rats. Mol Cell Biochem. 2004 261: 35-42. 15- Paolisso G, D'Amore A, Giugliano D, Ceriello A, Varnicchio M, D'Onofrio F. Pharmacological doses of vitamin E improve insulin action in healthy subjects and non- insulin-dependent diabetic patients. Am I Clin Nutr. 1993 57: 650-6. 16- Khanduja KL, Avti PK, Kumar S, PathaniaV, Pathak CM. Inhibitory effect of vitamin E on proinflammatory cytokines-and endotoxin- induced nitric oxide release in alveolar macrophages. Life Sci. 2005 76(23): 2669-80. 17- Azzi A, Ricciarelli R, Zingg JM. Non-antioxidant molecular functions of alpha-tocopherol (vitamin E). FEBS Lett. 2002 519: 8-10. 18- Li RK, Cowan DB, Mickle DA, Weisel RD, Burton GW. Effect of vitamin E on human glutathione peroxidase (GSH-PX1) expression in cardiomyocytes. Free Radic Biol Med. 1996 21: 419-426. 19- Yoo KY, Hwang IK, Kim JD, Kang IJ, Park J, Yi JS, Kim JK, Bae YS, Won MH. Antiinflammatory effect of the ethanol extract of Berberis koreana in a gerbil model of cerebral ischemia/ reperfusion. Phytother Res. 2008 22: 1527-32. 20- Zhu F, Qian C. Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1beta and inducible nitric oxide synthase in the rat model of Alzheimer’s disease. BMC Neurosci. 2006 7: 78. 21- Yu Y, Liu L, X Wang, et al. Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies. Bioche Pharmacol. 2010 79(7): 1000-6. 22- Jialal I, Venugopal SK. Oxidative strees, inflammation, and diabetic vasculopathies: the role of alpha tocopherol therapy. Free Radic Res. 2002 36(12): 1331-6. 23- Ziaei S. A randomized placedbo controlled trial to determine the effect of vitamin E in treatment of primary dysmenorrheal. BJOG. 2001 108(11): 1181-30. 24- Calfee Mason KG, Lee EY, Spear BT, Glauert HP. Role of the p50 subunit of NF-kappa β in vitamin E-induced changes in mice treated with the peroxi some proliferator, ciprofibrate. Food Chem Toxicol. 2008 46: 2062-2073. 25- Kuznetsova LP, Sochilina EE, Faddeeva MD, Iagodina OV. Effect of some isoquinoline alkaloids on enzymatic activity of acetylcholinesterase and monoamine oxidase. Ukr Biokhim Zh. 2005 77: 147-153. 26- Peng WH, Lo KL, Lee YH, Hung TH, Lin YC. Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. Life Sci. 2007 81: 933-8. 27- Peng WH, Wu CR, Chen CS, Chen CF, Leu ZC, Hsieh MT. Anxiolytic effect of berberine on exploratory activity of the mouse in two experimental anxiety models: interaction with drugs acting at 5-HT receptors. Life Sci. 2004 75: 2451-62. 28- Dhir A, Kulkarni SK. Effect of addition of yohimbine (alpha-2-receptor antagonist) to the antidepressant activity of fluoxetine or venlafaxine in the mouse forced swim test. Pharmacol. 2007 80: 239-43. 29- Yoo JH, Yang EM. Inhibitory effects of berberine against morphine-induced locomotor sensitization and analgesic tolerance in mice. Neuroscience. 2006 142(4): 953-61. 30- Vatassery GT. Vitamin E and other endogenous antioxidants in the central nervous system. Geriatrics. 1998 53: 525-527. 31- Biessels GJ, Kerssen A, de Haan EH, Kappelle LJ. Cognitive dysfunction and diabetes: implications for primary care. Prim Care Diabetes. 2007 1(4): 187-93. 32- Tuma I. Diabetes mellitus and cognitive impairments. Vnitr Lek. 2007 53(5): 486-8. 33- Manning PJ, Sutherland WH, Walker RJ, et al. Effect of high-dose vitamin on insulin resistance and associated parameters in overweight subjects. Diabetes Care. 2004 27: 2166-1. 34- Salonen, JT, Nyyssonen K, Tuomainen TP, et al. Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men. BMJ. 1995 311: 1124-7. 35- Knekt P, Reunanen A, Marniemi J, Leino A, Aromaa A. Low vitamin E status is a potential risk factor for insulin-dependent diabetes mellitus. J Intern Med. 1999 245: 99-102.

R Rezaei, A Almasi-Hashiani , A Rashidi , Sm Vaez, A Khosravi ,
Volume 24, Issue 103 (4-2016)

Background and Objective: Macular edema is an important cause of visual loss in diabetic patients which can lead to permanent vision loss in untreated cases. This study compares the efficacy of intravitreal injection and the sub-tenon capsule of triamcinolone on the visual acuity in patients with diabetic retinopathy.

Materials and methods: In this randomized clinical trial study, 82 diabetic retinopathy eyes were randomly assigned to intravitreal triamcinolone injection group and 74 eyes to sub tenon capsule injection. In terms of visual acuity and intraocular pressure, patients were followed up after first week, first month, and 3rd month. The collected data were analyzed using ANOVA with repeated data (Repeated ANOVA) and  Stata software (version 13).

Results: Crude comparison between groups  did not exhibit significant differences. However, by controlling the confounding baseline effect, level of visual acuity, logMar[d1]  of the visual acuity in the  intravitreal injection group (-0.78) was significantly less than the sub-tenon capsule group (-0.67). Also, after controlling for other confounding variables (age and sex), the mean IOP was significantly higher in the intravitreal injection group.

Conclusion: [d2] Visual acuity in intravitreal injection group was significantly less than the sub-tenon capsule group and also the mean IOP was higher in the intravitreal injection group. Therefore, sub-tenon capsule of triamcinolone stands out as a superior approach.

Fatemeh Noori Roshnavand, Vida Hojati, Gholamhassan Vaezi, Raheleh Rahbarian,
Volume 27, Issue 125 (November & December 2019)

Background and Objective: Diabetes causes fertility disorders by interfering with the endocrine gland function. There are reports that, green tea and catechins could have anti-oxidant and hypoglycemic properties. Therefore, in the present study, we evaluated the effects of green tea aqueous extract and catechin influence on pituitary-gonadal axis in rat models of type 1 diabetes.
Materials & Methods: Six groups of Wistar rats (8 in each group), including control, diabetic control (intraperitoneal injection (IP) of 0.5 mL saline solution for 30 days after induction of diabetes), diabetic treated with 100 and 200 mg/kg doses of green tea aqueous extract (IP injection of 0.5 mL green tea extract for 30 days), and diabetic treated with 100 and 200 mg/kg doses of catechin (IP injection 0.5 mL of catechin for 30 days) were used. The induction of diabetes was conducted through an IP injection of 240 mg/kg alloxan. At the end of the treatment course, the serum levels of LH, FSH, estrogen, testosterone, dihydrotestosterone and cytoplasmic HOdG-8 in testicular tissue were measured by ELISA method. ANOVA and Tukey post hoc test (P<0.05) were used to perform the data analysis.
Results: The incorporation of 200 mg/kg green tea extract and 100 and 200 mg/kg concentrations of catechin, in comparison with the diabetic control group, led to a significant dose-dependent increase in the serum level of LH, FSH, estrogen, testosterone, and dihydrotestosterone. A dose-dependent significant decrease was observed in HOdG-8 in the testicular tissue of diabetic rats (P<0.05).
Conclusion: Based on the obtained data, compared to green tea, catechin considerably enhanced the hormonal parameters and reduced HOdG-8 in testicular tissue of diabetic rats.

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