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M Dadashpour, I Rasooli, F Sefidkon, M Taghizadeh, Sh Darvish Alipour Astaneh,
Volume 19, Issue 77 (6-2011)

Background and Objective: Utilization of plants as antioxidants in food processing has a potential for substitution of synthetic antioxidants. In the present work, some unexplored biological activities of Thymus daenensis, commercial thyme essential oils and thymol were comparatively studied. Materials and Methods: Ferrous ion chelating was assessed by spectrophotometry by mixing the essential oils with diluted FeSO4 followed by addition of ferrozine. Antioxidative properties were assessed by beta carotene bleaching and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging tests. Gallic acid equivalent of ferric reduction was carried out using FeCl3. Super oxide anion radical scavenging was determined using xanthine oxidase and anti tyrosinase inhibitory activity was determined by a spectrophotometry method using a modified dopachrome method with L-DOPA as the substrate. Results: Chelating reaction of T. daenensis oil was dose dependent, and its super oxide anion radical scavenging property was higher than the commercial oil. Lipid peroxidation inhibition by T. daenensis oil was stronger and those of the commercial oil and thymol were approximately equal. DPPH free radical scavenging property of T. daenensis oil was higher than trolox, butylated hydroxytoluene and anisol (BHT and BHA). Ferric-reducing antioxidant power (FRAP) of T. daenensis oil was greater. The total phenolics anti tyrosinase IC50 were also determined. Conclusion: The results point to the nutritional value of these plants in preventing formation of toxic reactive oxygen species, and show that Thymus daenensis, as a good antioxidant, can directly scavenge free radicals. The results from biological properties of Thymus daenensis are indicative of its potentials for use in food and drug industries.

M Babamiri, M Vatankhah, H Masumi Jahandizi, M Nemati, M Darvishi,
Volume 21, Issue 84 (3-2013)

Background and Objective: Because of the importance of happiness in giving up substance abuse the aim of this study was to investigate the correlation between coping styles, negative automatic thoughts, and hope with happiness in the addicts referred to Ahvaz drug abuse rehabilitation centers. Materials and Methods: The study population comprised of 100 addicts whom were referred to Ahvaz drug abuse rehabilitation clinics during the year 2011. Participants were selected by convenience sampling method and response to the Parker and Andler coping styles, Miller hope scale, Oxford happiness inventory, and Kendall and Hollon negative automatic thought questionnaires. Results: Our results indicate that there is a significant relationship between coping styles, negative automatic thoughts, and hope with happiness in the addicts. Regression analysis showed that predictive variables were able to predict 60% of happiness, with problem-oriented coping style and hope being the best predictors of happiness. Conclusion: Improving problem-oriented coping style and hope can play a great role in happiness and improving the rate of rehabilitation and recovery in addicts.

Sma Shariatzadeh, A Hamta, M Soleimani, S Darvishi,
Volume 22, Issue 94 (7-2014)

Background and Objective: Breast cancer is the most common cancer among women worldwide. Saffron is one of the most well-known plants as an antioxidant and anticancer. The aim of this study was to assess the impact of saffron on the viability of breast cancer cells and simultaneous interaction effect of Paclitaxel drug. Materials and Methods: In this study, saffron extract (Crocus sativus L.) was prepared by Soxhlet method. Breast cancer cells (4T1) were prepared from the Pasteur cell bank then passaged several times until the required number of cells obtained. Cytotoxicity of Paclitaxel and the extracts of saffron were assessed separately and simultaneously using colorimetric MTT assay and trypan Blue test with certain concentrations of drug and extracts in the treatment period of 48 and 72 h. Then, the rate of apoptogenic changes in each compound was evaluated by Hoechst and PI methods. Results: Data from 48 and 72 h treatment of extract of Crocus sativus showed antitumor effects on breast cancer cells. These effects were dose and time dependent. The synergistic effects in 48 hour treatment indicated a significant increase in cytotoxicity of saffron/Paclitaxel (P <0.05). Conclusion: The results showed that ethanol and aqueous extract of saffron and Paclitaxel have significant anticancer properties against breast cancer cells. It was also found that the aqueous and ethanol extracts of saffron can considerably increase cytotoxicity in cancer cells induced by Paclitaxel while the aqueous extract of saffron showed better results. Referenses 1- Abdullaev Fl. Cancer chemoperventive and tumoricidal properties of saffron. Biol Med. 2002 227: 20-25. 2- Eisenberg D, Kessler R. Saffron redgold of brackish. Tehran Agricultural Information Bank. 1995. 3- Akhondzadeh S, Tahmacebi-Pour N, Noorbalaa A, et al. Crocus sativus L. In the treatment of mild to moderate depression: a double-blind, randomized and placebo controlled trial. Phytother Res. 2005 19(2): 148-51. 4- Sabzevari M. Unconventional medicine in United Statesprevalence, cost and pattern of use. N Engl Jmed 1993 328: 52-246. 5- Ampasavate C, Okonogi S, Anuchapreeda S. Cytotoxicity of extracts from fruit plants against leukemic cell lines. African J Pharmacy Pharmacol. 2010l 4(1): 13-21. 6- Okouneva T, Hillb T, The effects of vinflunine and vinblastin on centromere dynamis. Cancer. 2003 2(5): 427-36. 7- Gutheil W, Reed G, Ray A, Dhar A. Crocetin: an agent derived from saffron for prevention and therapy for cancer. Curr Pharm Biotechnol. 2012 13(1): 173-9. 8- Verdianrizi M,Hageakhondi A , Hamedani M,et al.Sepration of taxuspinanane G from (Taxus baccata L.). Plantpharmacology. 2010 4: 120-4. 9- Stephanie V, Paul Ch, John P, Noah G, Carolyn D. Erlotinib added to carboplatin and paclitaxel as first-line treatment of ovarian cancer:A phase II study based on surgical reassessment.Gynecologic Oncology. 2010 119: 451-6. 10- Chryssanthi D, Lamari F, Iatrou G, Pylara A, Karamanos N, Cordopatis P. Inhibition ofbreast cancer cell proliferation by style constituents of different crocus species. Anticancer Res. 2007 27: 357-62. 11- Samarghandian S, Boskabadi MH, Davoodi S. Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human lung cancer cell line. Pharmacognosy Magazine. 2010 6(24): 309-14. 12- Tavakkol-Afshari J, Brook A , Mousavi SH. Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. Food Chem. Toxicol. 2008 46: 3443-7. 13- Mark A, Marcus A, Jairo O, et al. Phase II trial of paclitaxel, ifosfamide, and carboplatin in extensivestagesmall cell lung cancer. Lung Cancer. 2003 40: 91-7. 14- Chakrabarty R, Das I. Saffron can prevent chemically induced skin carcinogenesis in swiss albino mice. Asian Pac J. 2004 5(1): 70-6. 15- Escribano J, Alonso G, Coca-Prados M, Fernandes J. Crocin safranal and picrocrocin from saffron inhibit the growth of human cancer cells in vitro. Cancer Letters Jurnal.1996 100(1): 23-30. 16- Tavakol-Afshari J, Rakhshandeh H, Brook A, Shahrokh abadi Kh. Study of cytutocity Saffron extract on carcinoma cell lines(HepG2). Azad Islamic University Jurnal. 2010 19(3): 154-9. 17- Mousavi S, Tavakol-Afshari J, Brook A, Jafari I. Role of caspases and Bax protein in Saffron-induced apoptosis in MCF-7 cells. Food & Chemical Toxicology. 2009 47: 1909-13. 18- Abdullaev F, Macvicar C, Frenkel G. Inhibition by selenium of DNA and RNA synthesis in normal and malignant cells in vitro. Cancer Lett. 1994 139: 43-49. 19- Mousavi S, Moallem SA, Mehri S, Shahsavand S. Improvement of cytotoxic and apoptogenic properties of crocin in cancer cell lines by its nanoliposomal form. Cancer. 2011 49(10): 1039-45. 20- Chang F, Li L, Wu C, Liu T, Peng F. Paclitaxel induced apoptosis in human gastric carcinoma cell lines. Cancer. 1996 77(1): 8-14. 21- Ashrafi M, Taghikhani M, Moosavi-Movahedi A. The effect of carotenoids obtained from saffron on histone H1 structure and H1–DNA interaction. International Journal of Biological Macromolecules. 2005 36(4): 246-52. 22- Ganeyan Z, Hosseinzadeh H. Effectes of saffronon polymerytion microtubule inbreast cancer cell line. Iran danesh. 2010 4(1): 31-9. 23- Abdullaev FI. Cancer chemopreventive andtumoricidal properties of saffron (crocus sativusL.). Exp Biol Med. 2005 227: 20-5. 24- Premkumar K, Thirunavukkarasu C, AbrahamSK, Santhiya ST, Ramesh A. Protective effect of saffron (Crocus sativus L.) aqueous extract against genetic damage induced by anti-tumor agents in mice. Hum Exp Toxicol. 2006 25: 79-84. 25- Hosseinzadeh H, Sadeghnia HR. Effect of safranal, a constituent of crocus sativus (saffron), on methyl methanesulfonate (MMS)-induced DNAdamage in mouse organs: An alkaline single-cell gel electrophoresis (comet) assay. DNA and Cell Biol. 2007 26 (12): 841-6.

Islami M, Mortazavi Y, Soleimani M, Soleimanifar F, Nadri S, Hosseinzadeh S, Darvish M,
Volume 26, Issue 117 (9-2018)

Background and Objective: Umbilical Cord blood (UCB) hematopoietic stem cell (HSC) transplantation is a therapeutic approach for the treatment of malignant and non-malignant hematologic disorders due to ease of collection, lack of risk for donors and lower levels of infection. Moreover, it is considered a good alternative for bone marrow HSC transplantation. The main limitation of their use is insufficient amount of HSCs due to low volume of blood collected from umbilical cord. A possible solution to overcome this limitation may be the in vitro expansion of these cells on 3D nanofiber scaffolds, with the goal of natural niche’s topography and chemistry mimicking.
Materials and Methods: In this study, MACS isolated CD133+ cells were confirmed via flow cytometry and then cultured in three conditions:  2-dimensional culture (2D), 3D PLLA scaffold and collagen-fibronectin coated PLLA scaffold.
  • : Comparison between three aforementioned groups showed that collagen-fibronectin coated scaffold had the highest expansion level CD133+ cells, while also having the highest clonogenic capacity and biocompatibility.
Conclusion: The results of this study showed that the protein coating of 3D PLLA scaffold with collagen-fibronectin provides a suitable system for the expansion of cells with minimal differentiation in vitro.

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