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, , ,
Volume 1, Issue 2 (3-1993)
Abstract


, ,
Volume 3, Issue 9 (12-1994)
Abstract


, , , , ,
Volume 11, Issue 42 (Mar 2003)
Abstract


, , ,
Volume 13, Issue 50 (Mar 2005)
Abstract

Background and Objectives: One of the complications arising from the consumption of Cuminum Cyminum is reproductive system disorders in humans and animals. Since there has been no comprehensive research on the effect of this herbal medicine on spermatogenesis and production of testosterone in males, the present study was carried out with the aim of determining the effect of Cuminum Cyminum alcoholic extract on spermatogensis and testosterone production in adult male wistar rats in Kazeroon in 2004. Materials and Methods: In this experimental research 50 male wistar rats were divided into 5 groups of 10. Following the bioassay LD50 (lethal dose) of the compound was determined to be 120 mg/kg and concentrations of 30,60 and 100 mg/kg as sublethal doses were injected into peritoneum every other day for 21 days in three treatment groups. The two remaining groups received the solvent (distilled water) and no compound. The results were analysed through one-way analysis of variance and t-test. Results: The results showed that 100 mg/kg of Cuminum Cyminum alcoholic extract reduced serum testostrone level by 71.5% (P=0.05), while it had no significant effect on serum FSH and LH levels. Histological investigations of testis showed a decline of 19.7%, 48.3% and 89.5% sperm cells in doses 30, 60 and 100 mg/kg respectively. However, no adverse effect was observed owing to the injection. Conclusion: According to the research results it can be stated that Cuminum Cyminum alcoholic extract at 100 mg/kg of rats has probably caused the weakened function and reduced testosterone level and spermatogenesis through direct effect on testicular tissues. Research concerning the ultra structure studies of testis and the effect of the plant on hormone level in hypothalamus and fetus growth is recommended.


, , ,
Volume 13, Issue 51 (Jun 2005)
Abstract

Background & Objectives: Zinc as a heavy metal is known to be an environment pollutant. Research shows that high amount of this metal might pose health hazards by affecting the normal function of endocrine glands and metabolic activities. Thus, this study was conducted with the aim of determining the effect of various amounts of zinc on thyroid gland and liver enzymes in adult male rats in Kazeroon in 2005. Materials & Methods: In this experimental study 40 adult male wistar rats were classified in to experimental, control and sham groups. Experimental groups received zinc in from of oral zinc sulfate 20 , 40 and 80 mg/kg for 15 days in three subgroups . Sham group received 1 ml distilled water while control group received no substance. At the end of 15th day blood sample was taken from ventricular part of the heart and concentrations of T3, T4 and TSH hormones and AST, ALT and ALP enzymes were measured through ELISA and trade kits and the data were analysed using Tukey test . Results: The results showed no significant difference in T3 hormone concentration and ALP enzyme between experimental groups and control group, while T4 hormone concentration in the first experimental group (20mg/kg zinc sulfate) increased significantly compared with control group (P<0.05). The concentration of TSH hormone showed a significant decrease between experimental and control groups (P<0.05). Serum concentration of AST and ALT in the first experimental group increased significantly compared to control group while it showed a significant decrease in the second and third experimental groups (40 and 80 mg/kg zinc sulfate) (P=0.05). Conclusion: The study results indicate that zinc affects thyroid gland and blocks the activity of 5'- diodinase through binding to sulfhydryl groups and decreases the conversion of T4 to T3. Zinc also decreases TSH amount and can damage plasma membrane and increase the amount of AST and ALT enzyme.


M Shariati, E Sharifi, M Kaveh,
Volume 15, Issue 61 (12-2007)
Abstract

Background and Objective: The pit of Phoenix dactylifera contains different chemical compounds such as saturated and unsaturated fatty acids, Zinc(Zn), Cadmium(Cd), Calcium(Ca), and potassium(K). Saturated fatty acids include stearic and palmitic acid and unsaturated fatty acids contain linoleic and oleic acids which could inhibit 5- - reductase enzyme. The present study was carried out with the aim of determining the effect of phoenix dactylifera pit powder on spermatogenesis and testosterone level in adult male rats.

 Materials and Methods: In this experimental research 45 wistar male rats were divided into 5 groups of 9 including the control group receiving no treatment, the saline group receiving an equal volume of normal saline as a solvent and the treatment groups receiving 0.05, 0.1 and 0.2 mg/kg body weight of Phoenix dactylifera pit powder orally for 21 days. The results were analysed through Excell, One-way analysis of variance and t-test.

 Results: The results showed that 0.1 and 0.2 mg/kg body weight of the powder increased the testosterone level significantly compared to the control and saline groups (P<0.05), whereas no significant change was observed in serum FSH and LH levels. Likewise, the above- mentioned amounts reduced dihydrotestosterone level in treatment groups (P<0.05). Histologic exam of the testis showed an increase in sperm density in seminiferous tubules of treatment groups (P<0.05).

 Conclusion: According to the research results it can be stated that the powder of phoenix dactylifera pit has probably caused increased testosterone level and decreased dihydrotestosterone level via inhibiting 5- - reductase enzyme induced by palmitic, stearic, linoleic, and oleic acids.



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