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Showing 27 results for شریفی

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Volume 6, Issue 22 (3-1998)
Abstract


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Volume 9, Issue 36 (9-2001)
Abstract


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Volume 10, Issue 41 (12-2002)
Abstract


B Falak-Ul-Aflaki, F Sharifi, Z Torabi, F Moezi,
Volume 15, Issue 58 (3-2007)
Abstract

Background & Objectives: Nocturnal enuresis, the involuntary passing of urine during sleep after the age at which bladder control would normally be anticipated, is a widespread and potentially disabling disorder of children. Treatment of enuresis includes non-pharmacologic and pharmacologic procedures. Imipramine, anticholinergics, and desmopressin are appropriate drugs for treatment. Desmopressin is a synthetic analogue of vasopressin, which decreases urine output. Since efficacy and side effects of desmopressin-therapy differ in various studies, this research was conducted to evaluate the efficacy of desmopressin in enuretic children in Zanjan. Materials & Methods: In this quasi-experimental study, 126 chidren aged 5-14 suffering from primary nocturnal enuresis, referring to pediatric nephrology clinit were entered into the study during 2002-2006. Following the written consent a questionnaire concerning the personal data and physical examination was completed for each patient. Clinical tests including U/A, U/C, Cr and serum electrolytes were carried out and after rejecting the secondary causes of enuresis 10-20 g intransal desmopressin was prescribed according to the age and weight of the children. The effect and complications of the drug were followed up monthly for six months. Results: Of 126 children, 56 (44.4 %) obtained full recovery, and 48 (38.1%) partial recovery from nocturnal enuresis. The total recovery was 82.5 %. 22 patients (17.4 %) did not respond to the drug. No significant difference was observed between age, gender, existence of stress, and effect of the drug on child enuresis. Children with familial history of nocturnal enuresis responded better to the drug. No complications were observed in patients. Conclusion: Desmopressin is an effective drug against nocturnal enuresis of children. The drug is more effective in children with familial history of primary nocturnal enuresis.


V Zanburi, S Kalantari, F Sharifi,
Volume 15, Issue 60 (5-2007)
Abstract

Background and Objective: Although patients with uncontrolled type 2 Diabetes mellitus(DM) despite conventional treatment with oral hypoglycemic agents eventually require insulin to achieve glycemic control, most of them reject use of insulin. To evaluate the efficacy of adding acarbose to full doses of conventional oral hypoglycemic agents on the metabolic control of the patients this study was designed. Materials and Methods: In this uncontrolled follow-up study, 20 patients with type 2 DM and persistent poor glycemic control despite maximal doses of sulfonylurea and metformin were recruited to receive additional treatment with acarbose. Insulin therapy was rejected by all the patients and 12 weeks of dietary reinforcement and supervision for their diet and exercise programs failed to improve their glycemic control. An active treatment period with acarbose 100 mg thrice daily was fallowed by a 12-week of placebo. Efficacy was assessed by changes in HbA1c, fasting and 2-h postprandial plasma glucose and fasting plasma lipid levels. Results: Acarbose treatment was associated with significantly greater reductions in HbA1c (-1.3 +/- 0.2% vs. placebo 0.2 +/- 0.1%, P = 0.038), Fasting Plasma Glucose(FPG)(-25.3 +/-10 mg/dl vs. placebo 10 +/- 6mg/dl , p:0.019), 2-h postprandial glucose (-24 +/- 8 mg/dl vs. placebo 15+/- 7.5 mg/dl, P :0.001) and body mass index(BMI) (-0.5 +/- 0.32 kg/m² vs. placebo 0.42 +/- 0.29 kg/ m², P: 0.01). There were no significant changes in plasma lipids levels. Conclusion: In patients with type 2 DM inadequately controlled on conventional oral agents, acarbose resulted in beneficial effects on glycemic control and mean body weight. Additional use of acarbose can be considered as a useful alternative in such patients if they are reluctant to accept insulin therapy.


M Shariati, E Sharifi, M Kaveh,
Volume 15, Issue 61 (12-2007)
Abstract

Background and Objective: The pit of Phoenix dactylifera contains different chemical compounds such as saturated and unsaturated fatty acids, Zinc(Zn), Cadmium(Cd), Calcium(Ca), and potassium(K). Saturated fatty acids include stearic and palmitic acid and unsaturated fatty acids contain linoleic and oleic acids which could inhibit 5- - reductase enzyme. The present study was carried out with the aim of determining the effect of phoenix dactylifera pit powder on spermatogenesis and testosterone level in adult male rats.

 Materials and Methods: In this experimental research 45 wistar male rats were divided into 5 groups of 9 including the control group receiving no treatment, the saline group receiving an equal volume of normal saline as a solvent and the treatment groups receiving 0.05, 0.1 and 0.2 mg/kg body weight of Phoenix dactylifera pit powder orally for 21 days. The results were analysed through Excell, One-way analysis of variance and t-test.

 Results: The results showed that 0.1 and 0.2 mg/kg body weight of the powder increased the testosterone level significantly compared to the control and saline groups (P<0.05), whereas no significant change was observed in serum FSH and LH levels. Likewise, the above- mentioned amounts reduced dihydrotestosterone level in treatment groups (P<0.05). Histologic exam of the testis showed an increase in sperm density in seminiferous tubules of treatment groups (P<0.05).

 Conclusion: According to the research results it can be stated that the powder of phoenix dactylifera pit has probably caused increased testosterone level and decreased dihydrotestosterone level via inhibiting 5- - reductase enzyme induced by palmitic, stearic, linoleic, and oleic acids.


F Sharifi, L Perse, Gr Ahmadi, Sn Mousavinasab,
Volume 15, Issue 61 (12-2007)
Abstract

Background and Objective: Although there are several methods of treatment of osteoporosis, prospective studies to compare their effect on bone density in Iranian population are rare. This study was designed to compare the effect of alendronate and hormone replacement therapy on bone mineral density of postmenopausal Iranian women living in Zanjan.

 Materials and Methods: We treated 115 women (mean age 54/8±9 years). Twenty four women were treated with conjugated equine estrogen (0.625 mg), 5 mg medroxyprogesterone, and 1000 mg elemental calcium with 400 IU vitamin D daily. Forty four subjects received 10 mg/d alendronate plus calcium and vitamin D in the same dose and 37 women were taken placebo with 1000 mg/d calcium and 400 IU/d vitamin D. Their bone mineral densities (BMD) were measured at the lumbar spine, hip and mid radius every 12 months for three years. All cases with secondary osteoporosis were excluded from the study.

Results: Significantly a higher percentage increases in BMD at the lumbar spine (P< .008, 2-way analysis of variance) were found in the alendronate group than in the HRT and calcium + vitamin D groups throughout the 36-month study period. However, there was no difference in BMD at the femoral neck and mid-radius between alendronate and HRT groups. Treatment with alendronate resulted in a 11% increase at the L-spine BMD (P: 0/00). A non significant reduction of about 4% at the femoral neck BMD was detected in alendronate group at the end of the 3-year study period. Although there was no significant change in the femoral neck, lumbar spine or mid-radius BMD with HRT, a significant decline (about 9%) in the BMD of the femoral neck was observed in the placebo group (P: 0.004). There was no difference in upper gastrointestinal or drug-related side effects between the groups.

 Conclusion: Our data suggest that the use of alendronate was well tolerated for 3 years and significantly increased BMD at the L-spine. It also can reduce the rate of BMD reduction at the femoral neck as was seen in the placebo group in postmenopausal Iranian women. Although HRT can inhibit BMD reduction at the femoral neck and lumbar spine, this regimen can not increase BMD in postmenopausal Iranian women.


M Mokhtari, S Sharifi, A Parang,
Volume 16, Issue 62 (3-2008)
Abstract

Background and Objectives: Dorema aucheri belonging to the umbrella family plants, is used as food by the local residents of the Southern Iran. It is believed that this plant contains medication properties. In this research, the effect of different qnuantities of Dorema aucheri extract on homogram in adult male rats were investigated. Materials and Methods: Forty adult male rats from wistar inbred were randomly divided into the following groups: control, sham operated and experimental groups. Experimental groups subdivided into three groups and received different doses of the plant alcoholic extract, 100, 200 and 400 mg/kg for 30 days. The sham group recieved normal saline and the control group received nothing. At the end of 30th day, blood was taken from ventricle of the heart of the rats from all groups followed by routine hematology tests. The whole numbers of white blood cells (WBC), red blood cells (RBC), hematocrit, MCV, MCH, MCHC, lymphocyte percentage and monocytes and platelets were measured and the results were analysed. Results: The results showed that using Dorema aucheri alcoholic extract at the end of 30th day, caused a significant increase in monocytes number in the experiment group comparing to the control group. The rate of platelet at the end of 30th day showed a significant decrease in the test group. Conclusion: The results indicated that Dorema aucheri probably contains flovonoidic component with antioxidant effect leading to the increase of monocytes and with inhibitory effect on thromboxane A2 production, causing a dicrease in platelet production.


F Sharifi, A Ashuri, Sn Mousavinasab,
Volume 16, Issue 65 (12-2008)
Abstract

Background and Objective: Due to a high prevalence of osteoporosis and its costs and regarding different ways of treatment for this disease and lack of knowledge about their efficacy in fracture rate in Iran, this study was designed in Zanjan to determine fracture rate in hypogonadal osteoporotic women who were on different types of anti-osteoporotic treatments. Materials and Methods: In this historical cohort study, 160 osteoporotic women were investigated. They were under treatment for their osteoporosis during 2001-2007. The cases were divided into 4 groups based on their type of treatment: 1) Calcium 1000 mg/daily + Vit D 200 IU/daily 2) Calcium 500 mg/daily + Vit D 200 IU/daily + Alendronate 10 mg/daily 3) HRT with Calcium D 4) Combination therapy. One group that didn't receive any type of treatment, were considered as control group. At least two densitometries were carried out in each case that the first one being done at the beginning of the study. Bone density was measured in three sites including: hip, spine and forearm with DEXA method. The rate of osteoporotic fractures was investigated in any site of the body during the follow-up period based on patient's invitation and their documents. Data were analyzed using Chi square, t-test, Logistic regression and Kaplan-Meier survival curve. Results: The rate of fracture was 11% (18 cases). Most of the fractures were non-vertebral (17 cases) and occurred in ages less than 50 years (17.9%). The most effective treatment to reduce fracture rate was Alendronate (with 69.9% reduction rate). HRT was as effective as Calcium and Vit D in reducing the fracture rates. Bone density in forearm region was known as the most vigorous predictive factor of fracture rate in our study. Most of the fractures were reported in forearm and leg regions (63.3%). Conclusion: Based on this study it can be concluded that Alendronate is the most effective treatment to reduce fracture rate in osteoporotic women. Densitometry is also recommended for women under 50 years old with hypogonadysm for early diagnosis and treatment. Keywords: Osteoporosis- Fragility fracture, Densitometry, HRT, Calcium D, Bisphosphonate.


H Rahmanpour, R Heidari, Sn Mousavinasab, F Sharifi, S Fekri,
Volume 17, Issue 67 (8-2009)
Abstract

Background and objective: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder among reproductive-age women. There is very little information about the prevalence of PCOS in Iran. With regard to the symptoms of PCOS which begin after menarche and regarding to its side effects on women's health, we aimed to determine the prevalence of PCOS in adolescents in Zanjan, Iran. Materials and Methods: In this descriptive community based study, 1882, 14-18 year old adolescents were randomly selected from Zanjan schools. The presence of PCOS was determined by the presence of olygomenorea, hirsutism, acne and androgenic alopecia. For correlation between PCOS and obesity, BMI and central obesity was evaluated. Statistical analysis was performed using K2 test. Results: PCOS was present in 54(2.9%), hirsutism was present in 161 (8.6%), acne was present in 220 (11.7%), androgenic alopsia was present in 130(6.9%) and menstrual irregularity was present in 281 (16.9%) of the cases. The prevalence of central obesity and over weight did not differ among the studied groups. Conclusion: The prevalence of PCOS in our study was similar to the results reported from other societies. With regard to PCOS side effects, we suggest that the diagnosis and treatment of PCOS is better to be started from adolescence.


Kh Hajimiri , Gh Sharifirad, A Hasanzade,
Volume 18, Issue 72 (11-2010)
Abstract

Background and Objective: High prevalence of dental disease in children is one of the essential reasons for oral health education. Use of right and correct educational pattern is a new way in health service field. The aim of this study was to determine the effect of oral health education based on health belief model for preventing carries and dental plaque on mothers who had 3-6 year old children. Materials and Methods: This quasi-experimental research was carried out on 56 mothers who had 3-6 year old children (28 women in control group and 28 in experimental group) in No 1 health center of Zanjan. The training was based on health belief model and certain behavior goals for about 60 minutes in 3 sessions. Mothers' functions were evaluated based on helping to brush the children's teeth and the number of brushing at zero and one month after the intervention time points. Finally, dental plaque was assessed based on Navy dental plaque index. Data was collected once in the first stage (before the intervention) and then in the second stage (after the intervention). Results: Mean score of all parts of health belief model in experimental group after educational intervention compared to before the intervention was increased significantly and also the mean score of all parts of health belief model was significantly increased after the intervention in experimental group comparing to control group. Conclusion: The results of this survey showed that by increasing the score of health belief model parts including perceived susceptibility, perceived severity, perceived benefits and perceived barriers, the preventive actions of oral health is also increasing. Therefore, results of this survey confirm the efficacy of health belief model in education of oral health.


H Nazem, F Sharifi, San Kazemi, Sn Mousavinasab, N Ghorovghi, S Boayni, A Mehhati,
Volume 19, Issue 75 (4-2011)
Abstract

Background and Objective: Resistin is a novel adipokine which may play a role in insulin resistance. In this study we aimed to determine the cord blood resistin, leptin, insulin and maternal serum resistin levels during pregnancy and to investigate correlation between these metabolic hormones and also to evaluate their association with newborn growth indices. Materials and Methods: This study was conducted on 80 newborns and their mothers in Mousavi Hospital Zanjan, Iran in 2009. Newborn growth indices including birth weight, height, body mass index (BMI), Ponderal index, Homeostatic Model assessment (HOMA-IR) and their mothers’ BMI were determined. Resistin, leptin and insulin levels were measured by ELISA. Results: In this study, cord blood resistin levels were higher than serum resistin levels of pregnant mothers (10.77±1.53 vs. 7.91± 5.71 ng/ml). Moreover, serum resistin levels of mothers’ did not exhibit any correlation with cord blood resistin, leptin and insulin levels, as well as neonatal anthropometric indices. Meanwhile, there was no significant correlation between cord resistin levels, insulin resistance, fat percentage and newborn growth factors. Cord resistin levels were positively correlated with cord blood leptin levels (r=0.222 p=0.048). Also, there was a significant positive correlation between cord blood leptin and neonatal BMI (r=0.223 p=0.047), Ponderal index (r=0.212 p=0.058), HOMA-IR (r=0.426 p=0.052) and fat percentage (r=0.247 p=0.014). Conclusion: On the basis of the findings, increased cord blood resistin levels may indirectly influence fetal growth through leptin or other cytokine levels. Though, further researches are needed to confirm this matter.


A Azarkeivan , Mh Arjangyan, B Hajibeigi, H Afradi, M Aghaeepour, F Razjoo, Sh Sharifi, P Eshghi,
Volume 19, Issue 75 (4-2011)
Abstract

Background and Objective: Leukocyte filters are effective for WBC reduction but they cannot inhibit passing plasma proteins and as a result repeated protein entry may produce allergic transfusion reactions. To deal with this problem, washed RBC method is used. The traditional wash method is an open system through which waste products are carried away in sewers with the risk of environmental pollution. Newly introduced approach for washed RBCs consists of a closed system whereby waste products enter into a bag. In this study, the two methods were compared. Materials and Methods: The Two open and close wash methods were compared in terms of health system, leukoreduction, risk of transmission of infection and quality control. In each method, 100 bags were washed, coded and then transmitted to different units of blood culture, flowcytometry as well as quality control. The data were collected and analyzed by SPSS14. Results: 200 bags (100 for each method) were studied. Microbiologically, there were no positive results for any of the methods. In quality control also there was not any significant difference in the two methods. In flowcytometry, we didn’t observe any significant correlation in leukocyte count in the two methods before washing (p=0.072), however.there was correlation between them after washing (p<0.0001), demonstrating that the new method was better for leukoreduction. Conclusion: The new washing system method was a superior way because it involves a close system where waste products are discharged into a side bag and disposed as hospital waste. Meanwhile, this approach is more convenient for leukoreduction. In our country, since we still need a washing system for some transfusions, this method is deemed to be a decent and practical one because it impedes environmental pollution.


F Sharifi, S Pirani, H Gholami,
Volume 19, Issue 77 (6-2011)
Abstract

Background and Objective: Linear growth is one of the most important criteria of general public health. As a micronutrient, zinc is known to affect linear growth. Considering the low prevalence of zinc deficiency in Zanjan, analysis of the impact of zinc deficiency in children with short stature in this province could provide valuable information. The aim of this study was to compare the serum concentration of Zinc in children with short stature and those with normal growth in Zanjan. Materials and Methods: This case–control study was conducted on two groups of school children under the age of 15, including 50 subjects with short stature, who were randomly selected from the patients of endocrine clinic of Vali-e-asr general hospital, and 50 normal-growth children. Normal subjects were selected from the cases classmates with the same socioeconomic situation. After collection of general health data and anthropometric measurements, blood samples were taken to detect serum concentrations of zinc in all of the participants. Results: One hundred children, including 50 males and 50 females, with a mean age of 10.2±3 years were investigated. Serum concentrations of zinc were significantly lower in the subjects with short stature (94±23.1 µg/dl vs. 110.9±12.4 µg/dl in normal subjects p: 0.001). A significant positive correlation was found between serum concentrations of zinc and the height of the subjects in both groups (r: 0.2, p: 0.02). Conclusion: There is a positive correlation between serum zinc concentration and the height of the children even in the zinc sufficient areas like Zanjan. Future studies for analysis of the impact of zinc supplementation on the growth velocity of subjects with zinc deficiency are recommended.


Mk Sharifi Yazdi, M Azarsa, Mh Shirazi, A Rastegar Lari, P Owlia, J Fallah Mehrabadi, H Molla Aghamirzaei, A Sabbaghi, F Shamkani, G Mobasseri, R Bakhtiari, Mm Soltan Dallal,
Volume 19, Issue 77 (6-2011)
Abstract

Background and Objective: The production of Extended Spectrum Beta Lactamases (ESBLs) by Escherichia coli is the main cause of resistance to Cephalosporins. In the past decade, CTX-M enzymes have become the most prevalent ESBLs in Europe, Canada, and Asia. In this study, the frequency of ESBL-producing E.coli and molecular detection of the CTX-M-I group was investigated. Materials and Methods: A total of 400 urine samples were collected from both hospitalized and out-patients in Khoy’s hospitals between November 2009 and April 2010. Out of these samples, 188 were identified as E.coli by standard biochemical tests. The antibiotic Susceptibility tests to 10 antibiotics were performed by the-disk-agar diffusion (DAD) method. ESBL production was screened by phenotypic test that including disk diffusion agar and combined disk as recommended by the Clinical and Laboratory Standards Institute (CLSI). Screened isolates were investigated by PCR assay for detection of CTX-M-I group genes. Results: The results show that out of 188 E.coli isolates identified, 56 (29.8%) were producing ESBls by phenotypic test. All isolates were sensitive to imipenem. Overall, 49 (87.5%) isolates were confirmed as CTX-M-I producer by PCR. Conclusion: The results of this study showed that about 30% of the identified E.coli were producing ESBl. Therefore, we recommend to use molecular methods in such researches.


Mm Soltan Dallal, S Hidarzadeh, M Azarsa, R Bakhtiari, Mk Sharifi Yazdi,
Volume 20, Issue 79 (5-2012)
Abstract

Background and Objectives: Previous studies have shown that polymyxin B sulfate and trimthoprim antibiotics are not individually effective on Yersinia enterocolitica and their closely related species. The aim of this study was to evaluate the synergistic effect of above antibiotics on Y. enterocolitica and their closely related species, from the clinical and the natural environment specimen collected in Iran, and compare them with the isolates that that were obtained from the Pasteur institute collection in France. Materials and Methods: In total, 73 species from Iran and 25 from the Pasteur institute in France were tested. The microdilution method was used for the MIC according to the standard protocol. Results: The synergistic effect was seen in all tested samples. However, the human species from the Pasteur institute were more sensitive than the Iranian human and the environmental species were less sensitive than clinical. The Y. enterocolitica isolates were less sensitive than the related species such as Y. intermedia, Y. fredriksenii, and Y. kristensenii. Conclusion: The synergistic effect polymyxin B sulfate and trimthoprim were more evident on other closely related Yersinia species Y. enterocolitica.


M Moodi, M Rezaeian, F Mostafavi, Gr Sharifirad,
Volume 21, Issue 84 (3-2013)
Abstract

Background and Objective: Breast cancer is the most common cancer and the second leading cause of cancer death among women worldwide. Mammography is a sensitive and specific test that is used for early diagnosis of breast cancer. Mammography screening behavior is one of the behaviors that early study on its stage of change can be used in proper planning and effective interventions for performing mammography screening behavior. This study was done with the aim of determining mammography screening behavior stage of change among women aged 40 and older in Isfahan. Materials and Methods: In this descriptive population-based study, 384 women aged 40 and older were recruited by random sampling method in the city of Isfahan. Mammography screening behavior stage of change was determined by the Rakoweski stage of change questionnaire. The data were analyzed by SPSS software using statistical chi-square and ANOVA at the significant level of α = 0.05. Results: The mean age of the women was 52.24 ± 8.22 years. The results indicate that 36.2%, 21.1%, 4.2%, 6.2%, and 32.3% of the women studied were in the stages of Pre-contemplation, Contemplation, Action, Maintenance, and Relapse, respectively. The statistical analysis show that there were some significant correlationship between age (p<0.0001), education (p= 0.009), married status (p= 0.011), insurance status (p= 0.025) and income level (p= 0.009) with the stages of change. Conclusion: Our results demonstrate that the majority of subjects were in the pre-contemplation and contemplation stages, and that a low percentage of women were in the action and maintenance stages. Therefore, appropriate intervention based on stage of change for promotion of mammography screening behavior seems to be essential.


F Sharifi, S Pirani, F Barzi, Z Shajari,
Volume 21, Issue 85 (4-2013)
Abstract

Background and Objective: Post-transplant diabetes mellitus (PTDM) is one of the problems occurring after kidney transplantation. This study was designed to detect the probable relationship between the glucose intolerance and serum and urinary concentrations of β2-microglobulin as well as their value to predict acute rejection of the transplant. Materials and Methods: In this cohort study, 40 patients without previous history of diabetes mellitus were enrolled serially. The glucose tolerance test and measurement of urinary and serum concentration of β2-microglobulin were done for all cases on days 3, 7, 11, and 21 after kidney transplantation. The relationship between short-term prognoses of the transplantation with blood glucose was analyzed by odd٬s ratio and correlations were also calculated. Results: Acute rejection of renal transplant was detected in 10% of the participants. At the third day after transplantation the rate of DM in subjects with and without transplant rejection was 75% and 35%, respectively (odd's ratio: 1.9, CI 95%: 0.2-20, p=0.09(. The rate of DM declined and reached to zero 21 days after the transplantation. There was a significant correlation between post glucose blood sugar concentration on day 3 and creatinine concentration on day 22 after the transplantation, which did not remain significant after adjustment for age. However, the significant correlation between the urine concentration of β2-microglobulin on day 11 after transplantation, and serum creatinine on day 21 remained constant after adjustments for age and sex. In the patients with transplant rejection, serum level of β2-microglobulin increased about four days before rises of creatinine. We did not find any correlation between blood glucose and β2-microglobulin concentrations. Conclusion: High incidence of post-transplantation glucose intolerance and DM was found after kidney transplantation especially at the first week after the transplantation. But we couldn’t find any relationship between post transplant diabetes mellitus (PTDM) and short-term prognosis of the kidney transplant.


Mm Soltan Dallal, A Rastegar Lari, R Bakhtiari, B Nikmanesh, Mk Sharifi Yazdi,
Volume 22, Issue 92 (5-2014)
Abstract

Background and Objective: Attention has largely been focused on appearance of multiple drug resistance enterococci in the last 20 years. One of the methods to overcome this problem is to combine different antibiotics in order to increase antimicrobial activity and reduce toxicity. The combination of fluor quinolones with other antibiotics has been widely investigated. The aim of this study was to investigate the synergistic effect of ciprofloxacin in several antibiotics Beta-lactam (piperacillin, ceftazidime and imipenem) on isolated enterococci. Materials and Methods: In this cross sectional study, 67 Streptococci strains were isolated from clinical samples from March to September 2012. The serial broth dilution method in test tubes was used for the MIC, and the check board Format was used for the synergistic effect of ciprofloxacin with Beta-lactam antibiotics. The synergistic effect was determined with four- fold reduction of initial MIC. Results: Totally, 67 strains of Streptococci were used, in which 50 strains (74.6%) were enterococci, 6(9%) were group B streptococcus, 5(7.5%) were non-group A streptococci, 2 (3%) were pneumococci, and 2 were strains of alpha streptococci (3%), respectively. All results were determined by the MIC and MBC of each antibiotic individually and also in combination with ciprofloxacin. Conclusion: The effect of ciprofloxacin on other antibiotics was indifferent, and the synergistic effect was not observed.


Mm Soltan Dallal, Mk Sharifi Yazdi,
Volume 22, Issue 93 (6-2014)
Abstract

Background and Objective: Occurance of severe diseases by bacteria that are considered as normal flora poses a threat to human life. Bacteria such as Klebsiella, Enterobacter, and Serratia, which are all VP +, cause the urinary tract infection. The antibiotic-resistant strains of these bacteria create problems in the process of treatment. The aim of this research was to compare the multiple antibiotic resistance patterns of Klebsiella, Enterobacter, and Serratia causing urinary infections and determine the imipenem MIC in MDR strains. Materials and Methods: In this experimental study 400 urinary specimens from UTI patients who had referred to Imam Khomeini Hospital (Tehran) were collected using the midstream clean catch method. The klebsiella groups were identified by conventional methods. The antibiotic sensivity test was carried out by disk diffusion and macrodilution broth test methods. Results: Of 400 patients with urinary tract infections, 96 (24%) were caused by Klebsiella groups (KES. Maximum and minimum resistances were to amoxicillin and amikacin, respectivey. MIC and MBC determined using serial dilution method and showed that the concentration range of imipenem that stopped growth of Klebsiella pneumoniae and Serratia marcescens were in the range of 0. 25- 16 and 8-0.25 μg / ml, respectively. Conclusion: The results of this study suggest that imipenem is an appropriate medication for the treatment of Klebsiella group infections.



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