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B Pakpour, K Jafari, Z Bashiri, M Navaeian, M Piri,
Volume 21, Issue 87 (6-2013)
Abstract

Background and Objective: It has been shown that cannabinoids exert widespread effects on cognitive functions. An overlapping distribution of GABA with cannabinoid receptors has been reported in some brain structures such as dorsal hippocampus. Thus, the functional interactions between cannabinoid and GABAergic systems in cognitive control seem possible. The present study evaluated the potential role of cannabinoid CB1 receptors of the dorsal hippocampus on muscimol induced amnesia and muscimol state-dependent memory in adult male mice. Materials and Methods: In this experimental study 250 adult male NMRI mice were entered. Drugs of muscimol and ACPA were used. Mice were anaesthetized and cannulae implantation was bilaterally used in the CA1 regions of the dorsal hippocampus via stereotaxic method. Seven days after recovery from surgery, the behavioral testing was started by means of inhibitory avoidance task. Results: Post-training injection of muscimol (0.075, 0.15 µg/mouse) impaired inhibitory avoidance memory. The memory impairment induced by ACPA (0.15 µg/mouse) was completely reversed by pre-test administration of ACPA and/or muscimol, suggesting muscimol induced state-dependent memory. Conclusion: These results suggest that cannabinoid CB1 receptors of the dorsal hippocampal may play an essential role in muscimol-induced amnesia and muscimol state-dependent memory in mice.


Doosti F, Pakpour B, Navaeian M,
Volume 26, Issue 117 (9-2018)
Abstract

Background and Objective: It has been shown that the opioidergic system exerts widespread effects on cognitive functions. Interactions between opioid and serotonin receptors have been reported in some brain structures such as the dorsal hippocampus, thus a functional interaction between opioids and serotonin seems possible concerning memory control. The purpose of this study was to assess the effects of CA1 5-HT3 receptor agonist on memory acquisition deficit induced by morphine.
Materials and Methods: In this study, we used 96NMRI mice. These mice were divided into twelve equal groups that received different doses of 5-HT3recepto ragonist, different doses of morphine and a combination of morphine and serotonin 5-HT3 receptor agonist. Morphine was injected into the peritoneum, while 5-HT3 receptor agonist M-Chlorophenylbiguanide (M-chl) was administered via intra-hippocampal injection. A step-down passive avoidance test was used for the evaluation of memory.
Results: Pre-training intra-peritoneal administration of morphine (5 mg/kg) induced amnesia. Moreover, pre-training intra-CA1 administration of 5-HT3 receptor agonist (M-Chl) (0.5 ng/mouse) impaired memory acquisition. Furthermore, intra-CA1 injection of M-Chl (0.005ng/mouse) reversed impairment of memory acquisition induced by morphine (5 mg/kg).
Conclusion: The results demonstrated the existence of a synergistic effect between hippocampal 5-HT3 receptor agonists and opioidergic receptors.
 

 

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