Volume 22, Issue 95 (8-2014)                   J Adv Med Biomed Res 2014, 22(95): 112-121 | Back to browse issues page

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Abtahi froushani S M, Esmaeili Gouvarchin Ghaleh H, Rezapor R, Mansori Motlagh B, Rostaei A. Immunomodulatory Effects by Hydroalcoholic Liquorice Root Extracts. J Adv Med Biomed Res. 2014; 22 (95) :112-121
URL: http://zums.ac.ir/journal/article-1-2885-en.html
1- Dept. of Microbiology, Veterinary Faculty, Urmia University, Urmia, Iran , meysamabtahi@hotmail.com
2- Dept. of Microbiology, Veterinary Faculty, Urmia University, Urmia, Iran
Abstract:   (42549 Views)

Background and Objective: The roots of Glycyrrhiza glabra (Liquorice) have long been used in traditional medicine to treat a variety of ailments from simple coughs to hepatitis and even more complexities such as cancers. This study was conducted to grasp the immunomodulatory properties of the roots of Glycyrrhiza glabra in NMRI-mice challenged with sheep red blood cells (SRBCs). Materials and Methods: The study population consisted of 20 male mice that randomly divided into two equal groups and immunized with SRBC. Mice in the treatment group orally received 0.75 g/Kg hydroalcoholic extract of Glycyrrhiza glabra every day from the beginning of the study for 2 weeks. Results: The results indicated a significant increase in the level of anti-SRBC antibody and simultaneously a significant decrease in the level of cellular immunity in the treatment group compared to the control group. Moreover, the level of the respiratory burst of phagocyte cells of splenocytes significantly decreased in the treatment groups, while the level of lymphocyte proliferation significantly increased in the treatment group as compared to the control group. Conclusion: Hydroalcoholic root extract of Glycyrrhiza glabra may be used as a natural source in immune system. References 1- Amani M, Sotudeh-Gharebagh R, Mostaoufi N, Kashani H. Optimal exteraction of glycyrrhetinic acid from licorice root. Technol. 2005 3(4): 376-580. 2- Nezamabadi H, Rahimiyan Mashhadi H, Zand A and Alizadeh H. Ecophysiological aspects of licorice rhizome. Plant Dis Pests. 1385 74(2): 45-62. 3- Marzi V, Circella G, Vampa GM. Effect of soil depth on the rooting system growth in Glycyrrhiza glabra L. Acta Horti. 1993 331: 71-8. 4- Nassirasl M and Hosseinzadeh H. Review of pharmacological effects ofglycyrrhiza sp. and its bioactive compounds. 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Type of Study: Clinical Trials |
Received: 2014/11/20 | Accepted: 2014/11/20 | Published: 2014/11/20

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