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Namdar F, Bahrami F, Bahari Z, Ghanbari B, Elahi S A, Mohammadi M T. Evaluation of the Effects of Fullerene C60 Nanoparticles on Oxidative Stress Parameters at Liver and Brain of Normal Rats. J Adv Med Biomed Res 2019; 27 (124) :8-15
URL: http://zums.ac.ir/journal/article-1-5745-en.html
Evaluation of the Effects of Fullerene C60 Nanoparticles on Oxidative Stress Parameters at Liver and Brain of Normal Rats
Fariba Namdar1 , Farideh Bahrami1 , Zahra Bahari1 , Bahram Ghanbari2 , Seyed Ahmad Elahi3 , Mohammad Taghi Mohammadi * 4
1- Dept. of Physiology and Medical Physics, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
2- Dept. of Chemistry, Sharif University of Technology, Tehran, Iran
3- Dept. of General Surgery, School of Medicine, Alborz University of Medical Sciences, Tehran, Iran
4- Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran , Mohammadi.mohammadt@yahoo.com
Abstract:   (146215 Views)

Background & Objective: The potent antioxidant property of fullerene C60 nanoparticles and their derivatives has been demonstrated in a wide range of in vitro and in vivo studies. Hence, we examined the effects of fullerene C60 on the oxidative stress parameters at brain and liver of rats in normal situation.
Materials & Methods: The study was performed in two groups of Wistar rats (each group, n = 6); normal and fullerene-treated normal animals. Treated rats received orally fullerene via oral gavage at dose of 1 mg/kg/day for 60 days. At termination of the study, the oxidative stress parameters were determined at brain and liver tissues, including the contents of glutathione (GSH) and malondialdehyde (MDA), and the activity of catalase (CAT) and superoxide dismutase (SOD). The t-test was used to analyze the data between two groups.
Results: Fullerene C60 treatment did not change blood glucose of treated rats compared to untreated rats. Fullerene C60 significantly increased the value of CAT activity (by 66%) and MDA levels (by 68%), whereas decreased SOD activity (by 33%) at liver of treated rats compared to untreated animals (P< 0.05). Fullerene administration significantly increased only CAT activity of brain in the treated rats (0.34±0.10 U/mg protein) compared to untreated animals (0.12±0.03 U/mg protein), (P<0.05).
Conclusion: Our findings indicated that oral administration of fullerene C60 nanoparticles differently changes the oxidative stress parameters in liver and brain at normal condition. It is suggested that these effects must be considered for application of these nanoparticles in various therapeutic purposes.

Keywords: Antioxidant, Fullerene, Oxidative stress, Nanomaterials
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✅ Our findings indicated that oral administration of fullerene C60 nanoparticles differently changes the oxidative stress parameters in liver and brain at normal condition. It is suggested that these effects must be considered for application of these nanoparticles in various therapeutic purposes.


Type of Study: Original Article | Subject: Life science
Received: 2019/08/10 | Accepted: 2019/11/14 | Published: 2020/02/8
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