Volume 29, Issue 133 (March & April 2021)                   J Adv Med Biomed Res 2021, 29(133): 83-91 | Back to browse issues page


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Sardari S, Mobaiend A, Ghassemifard L, Kamali K, Khavasi N. Therapeutic Effect of Thyme (Thymus Vulgaris) Essential Oil on Patients with COVID19: A Randomized Clinical Trial. J Adv Med Biomed Res. 2021; 29 (133) :83-91
URL: http://zums.ac.ir/journal/article-1-6197-en.html
1- Dept. of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
2- Dept.of Infectious Diseases, Vali-e-asr Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
3- Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
4- Dept. of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran , nxavasi@zums.ac.ir
Abstract:   (13579 Views)

 Background and Objective: SARS COV-2 is a worldwide pandemic disease. There is currently no effective cure for this virus, but some types of herbs can be a good choice for reducing its symptoms. There are some reports that Thymus Vulgaris has a high antioxidant compounds effective in strengthening the immune system, as well as anti-virus effects to reduce the respiratory symptoms. Therefore, we speculated that Thymus Vulgaris could be useful for reducing some of the symptoms in patients suffering from COVID- 19.
 Materials and Methods: First, thyme essential oil was prepared and a questionnaire regarding the patients’ symptoms was designed. Then, 83 patients with COVID-19 were randomly selected and divided into control group and thyme receiving group (TRG). The questionnaire was completed and emphasized to consume 5 mL of the syrup or essential oil three times per day. Finally, one week after the first visit, the questionnaire was completed again to determine the effects of thyme on the mentioned symptoms. Finally, the test results were reviewed and reported.
 Results: The results one week after taking thyme showed that, the fever (p<0.027), dizziness (p<0.003), cough, dyspnea, muscular pain, headache, anorexia, weakness and lethargy, fatigue, and chest wall pain were significantly reduced (p<0.001). Also, BUN (p<0.004), neutrophil count (p<0.001), and calcium (p<0.034) decreased but, lymphocyte count was increased significantly (p<0.001).
 Conclusion: Thyme plant which has high antioxidant properties, strengthens the immune system, and induces the antiviral effect could reduce the symptoms of coronavirus; therefore, it is recommended for reducing the symptoms of COVID-19.

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Thyme plant which has high antioxidant properties, strengthens the immune system, and induces the antiviral effect could reduce the symptoms of coronavirus; therefore, it is recommended for reducing the symptoms of COVID-19.


Type of Study: Clinical Trials | Subject: Clinical medicine
Received: 2020/09/3 | Accepted: 2020/11/16 | Published: 2020/12/4

References
1. Lau SK, Lee P, Tsang AK, et al. Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination. J Virol.2011;85(21):11325-37. [DOI:10.1128/JVI.05512-11]
2. Woo PC, Lau SK, Chu C-m, et al. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J Virol.2005;79(2):884-95. [DOI:10.1128/JVI.79.2.884-895.2005]
3. Peiris JSM, Chu C-M, Cheng VC-C, et al. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study.Lancet. 2003;361(9371):1767-72. [DOI:10.1016/S0140-6736(03)13412-5]
4. WHO. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. 2003.
5. Organization WHO. Middle East respiratory syndrome coronavirus (MERS-CoV). 2019.
6. Le Chang Y, Lunan Wang. Coronavirus disease 2019: Coronaviruses and blood safety. Trans Med Rev. 2020;34(2):75-80. [DOI:10.1016/j.tmrv.2020.02.003]
7. Balboni A, Battilani M, Prosperi SJM-QJoMS. The SARS-like coronaviruses: the role of bats and evolutionary relationships with SARS coronavirus. New Microbiol.2012;35(1):1. [DOI:10.1100/2012/989514]
8. Peiris J, Lai S, Poon L, et al. Coronavirus as a possible cause of severe acute respiratory syndrome.Lancet 2003;361(9366):1319-25. [DOI:10.1016/S0140-6736(03)13077-2]
9. Wu F, Zhao S, Yu B, et al. A new coronavirus associated with human respiratory disease in China.Nature. 2020;579(7798):265-9. [DOI:10.1038/s41586-020-2008-3]
10. Lu H. Drug treatment options for the 2019-new coronavirus (2019-nCoV). Biosci Trends. 2020;14(1):69-71. [DOI:10.5582/bst.2020.01020]
11. González-Molina E, Moreno DA, García-Viguera CJSh. Comparison of 'Verna'lemon juice quality for new ingredients and food products. Scientia horticulturae. 2009;120(3):353-9. [DOI:10.1016/j.scienta.2008.11.010]
12. Tang LI, Ling AP, Koh RY, Chye SM, Voon KGJBc. Screening of anti-dengue activity in methanolic extracts of medicinal plants. BMC Complement Altern Med. 2012;12(1):3. [DOI:10.1186/1472-6882-12-3]
13. Merchán Arenas DR, Muñoz Acevedo A, Vargas Méndez LY, Kouznetsov VVJSp. Scavenger activity evaluation of the clove bud essential oil (Eugenia caryophyllus) and eugenol derivatives employing ABTS+• decolorization.Sci Pharm. 2011;79(4):779-92. [DOI:10.3797/scipharm.1109-11]
14. Farahani M. Antiviral effect assay of Thymus Kotschyanus on HSV-1 multiplication.J Alborz Univ Med Sci. 2017;6(4):269-75. [DOI:10.29252/aums.6.4.269]
15. Fleming TJMEC. PDR® for Herbal Medicines™. Edited by Fleming T. New Jersey. 2000:224-5.
16. Organization WHO. WHO monographs on selected medicinal plants: World Health Organization; 1999.
17. Nabissi M, Marinelli O, Morelli MB, et al. Thyme extract increases mucociliary-beating frequency in primary cell lines from chronic obstructive pulmonary disease patients. Biomed Pharmacother. 2018;105:1248-53. [DOI:10.1016/j.biopha.2018.06.004]
18. Kordali S KR, Mavi A, Cakir A, Ala A, Yildirim A. Determination of the chemical composition and antioxidant activity of the essential oil of Artemisia dracunculus and of the antifungal and antibacterial activities of Turkish Artemisia absinthium, A. J Agri Food Chem. 2005;53(24):9452-8. [DOI:10.1021/jf0516538]
19. Sardai S, Fallahi F, Emadi F, et al. Pharmaceut Sci.
20. Mh A. Makhzan al-Advieh. Tehran: Tehran University of Medical Sciences. 2009;328.
21. Lewis SM, Williams A, Eisenbarth SC. Structure and function of the immune system in the spleen. Sci Immunol. 2019;4(33). [DOI:10.1126/sciimmunol.aau6085]
22. Santoyo S, Jaime L, García-Risco M, Lopez-Hazas M, Reglero GJIC, Products. Supercritical fluid extraction as an alternative process to obtain antiviral agents from thyme species. Indust Crops Products 2014;52:475-80. [DOI:10.1016/j.indcrop.2013.10.028]
23. Lenz E, Müller C, Mostafa A, et al. Authorised medicinal product Aspecton® Oral Drops containing thyme extract KMTv24497 shows antiviral activity against viruses which cause respiratory infections. J Herbal Med. 2018;13:26-33. [DOI:10.1016/j.hermed.2018.02.003]
24. Organization WHO. Almost a quarter of all disease caused by environmental exposure. 2006.
25. Schönknecht K, Krauss H, Jambor J, Fal AMJWl. Treatment of cough in respiratory tract infections-the effect of combining the natural active compounds with thymol. Wiadomosci lekarskie. 2016;69(6):791.
26. Salehi B, Mishra AP, Shukla I, et al. Thymol, thyme, and other plant sources: Health and potential uses. Phytother Res.2018;32(9):1688-706. [DOI:10.1002/ptr.6109]
27. Komaki A, Hoseini F, Shahidi S, Baharlouei NJJot, medicine c. Study of the effect of extract of Thymus vulgaris on anxiety in male rats. J Trad Complement Med. 2016;6(3):257-61. [DOI:10.1016/j.jtcme.2015.01.001]
28. Mohamed A, Omar AJN, Science. A study to find thyme oil dose that kill 50% of mice and minimal dose that kill all mice and maximum non-lethal dose.Nat Sci. 2013;11(12):52-3.
29. Büechi S, Vögelin R, von Eiff MM, Ramos M, Melzer JJCMR. Open trial to assess aspects of safety and efficacy of a combined herbal cough syrup with ivy and thyme. Complement Med Res. 2005;12(6):328-32. [DOI:10.1159/000088934]
30. Gruenwald J, Graubaum HJ, Busch RJA. Efficacy and tolerability of a fixed combination of thyme and primrose root in patients with acute bronchitis. Arzneimittelforschung. 2005;55(11):669-76. [DOI:10.1055/s-0031-1296916]
31. Lis-Balchin M, Hart SJJoe. A preliminary study of the effect of essential oils on skeletal and smooth muscle in vitro. J Ethnopharmacol. 1997;58(3):183-7. [DOI:10.1016/S0378-8741(97)00103-7]
32. Van Den Broucke C, Lemli JJPW. Spasmolytic activity of the flavonoids from Thymus vulgaris. Pharmaceutisch Weekblad. 1983;5(1):9-14. [DOI:10.1007/BF01959645]
33. Dashti-Zadeh F, Mahmoodi MM. The effect of aqueous and alcoholic extracts of thyme, eucalyptus, chamomile and fennel on virulence factors of Escherichia Coli, causative agent of urinary tract infection.J Alborz Univ Med Sci. 2017;6(4):257-68. [DOI:10.29252/aums.6.4.257]
34. Soltani M, Sheikhzadeh N, Ebrahimzadeh-Mousavi H, Zargar AJJoF, Science A. Effects of Zataria multiflora essential oil on innate immune responses of common carp (Cyprinus carpio).
35. J Fisheries Aquatic Sci
36. 2010;5(4):191-9.
37. Elhabazi K, Ouacherif A, Laroubi A, et al. Analgesic activity of three thyme species, Thymus satureioides, Thymus maroccanus and Thymus leptobotrys. African J Microbiol Res. 2008;2(10):262-7.
38. Akbar S. Thymus vulgaris L.(Lamiaceae). Handbook of 200 Medicinal Plants: Springer; 2020. p. 1795-810. [DOI:10.1007/978-3-030-16807-0_185]

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