Volume 22, Issue 95 (8-2014)                   J Adv Med Biomed Res 2014, 22(95): 122-131 | Back to browse issues page

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sadeghi F, Khalaj-Kondori M, Hosseinpour Feizi M A, Shaikhzadeh Hesari F. The Effect of Aqueous Extract of Boswellia on Spatial Learning and Memory in Adult Male Rats. J Adv Med Biomed Res. 2014; 22 (95) :122-131
URL: http://zums.ac.ir/journal/article-1-2886-en.html
1- Dept. of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
2- Dept. of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran , khalaj@tabrizu.ac.ir
Abstract:   (50986 Views)

Background and Objective: Learning is the acquisition of information about the world and memory is a mechanism to encode, store and retrieve the learned information. Weak memory and learning disorders are the most common cognitive problems. In the present study, the pharmacological effects of aqueous extract of Boswellia on learning and spatial memory in male rats was investigated using the Morris water maze (MWM) test. Materials and Methods: In this experimental study, 21 male rats were divided into 3 groups including a control group (distilled water) and two groups treated with aqueous extract of Boswellia (50 and 100 mg/kg) that received the treatment for 4 weeks. To evaluate learning ability of animals, Morris Water Maze was used. Results: In the first and the last day of training, all groups showed significant reduction in escape latency (P<0.0001) and traveled distance (P<0.0001). In the sixth day of training, both treatment groups showed significant reduction in escape latency (P<0.05) and traveled distance (P<0.05) in comparison with the control group. Conclusion: The results suggest that intake of Boswellia facilitates the learning and spatial memory formation in rats via Morris water maze test method. References 1- Sharifzadeh M, Sharifzadeh K, Naghdi N, Ghahremani MH, Roghani A. Posttraining intrahippocampal infusion of a protein kinase AII inhibitor impairs spatial memory retention in rats. J Neurosci Res. 2005 79(3): 392-400 2- Francis PT, Palmer AM, Snape M, Wilcock GK. The cholinergic hypothesis of Alzheimer’s disease: a review of progress. J Neurol Neurosurg Psychiatry. 1999 66(2): 137-47. 3- Abdel-Tawab M WO, Schubert-Zsilavecz M. Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Clin Pharmacokinet. 2011 50(6): 349-69. 4- Hussain H, Al-Harrasi A, Al-Rawahi A, Hussain J. 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Type of Study: Clinical Trials |
Received: 2014/11/20 | Accepted: 2014/11/20 | Published: 2014/11/20

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